ID   LPRB_MYCTU              Reviewed;         185 AA.
AC   P9WK53; L0T7T1; Q11045;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Putative lipoprotein LprB;
DE   Flags: Precursor;
GN   Name=lprB; OrderedLocusNames=Rv1274; ORFNames=MTCY50.08c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
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DR   EMBL; AL123456; CCP44030.1; -; Genomic_DNA.
DR   PIR; B70755; B70755.
DR   RefSeq; NP_215790.1; NC_000962.3.
DR   RefSeq; WP_003901123.1; NZ_NVQJ01000030.1.
DR   AlphaFoldDB; P9WK53; -.
DR   STRING; 83332.Rv1274; -.
DR   PaxDb; P9WK53; -.
DR   DNASU; 887011; -.
DR   GeneID; 887011; -.
DR   KEGG; mtu:Rv1274; -.
DR   TubercuList; Rv1274; -.
DR   eggNOG; COG1188; Bacteria.
DR   OMA; FIEWSIS; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR024520; DUF3558.
DR   Pfam; PF12079; DUF3558; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           25..185
FT                   /note="Putative lipoprotein LprB"
FT                   /id="PRO_0000018138"
FT   REGION          26..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           25
FT                   /note="N-palmitoyl cysteine; alternate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           25
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   185 AA;  19739 MW;  B412D6C748229453 CRC64;
     MRRKVRRLTL AVSALVALFP AVAGCSDSGD NKPGATIPST PANAEGRHGP FFPQCGGVSD
     QTVTELTRVT GLVNTAKNSV GCQWLAGGGI LGPHFSFSWY RGSPIGRERK TEELSRASVE
     DINIDGHSGF IAIGNEPSLG DSLCEVGIQF SDDFIEWSVS FSQKPFPLPC DIAKELTRQS
     IANSK