ID   LPRE_MYCTU              Reviewed;         202 AA.
AC   P9WK49; L0T935; P65312; Q11065;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Putative lipoprotein LprE;
DE   Flags: Precursor;
GN   Name=lprE; OrderedLocusNames=Rv1252c; ORFNames=MTCY50.30;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP44008.1; -; Genomic_DNA.
DR   PIR; D70752; D70752.
DR   RefSeq; NP_215768.1; NC_000962.3.
DR   RefSeq; WP_003406334.1; NZ_NVQJ01000049.1.
DR   AlphaFoldDB; P9WK49; -.
DR   STRING; 83332.Rv1252c; -.
DR   PaxDb; P9WK49; -.
DR   DNASU; 887064; -.
DR   GeneID; 887064; -.
DR   KEGG; mtu:Rv1252c; -.
DR   TubercuList; Rv1252c; -.
DR   eggNOG; ENOG5031HE2; Bacteria.
DR   OMA; PRSQQPW; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025971; LppP/LprE.
DR   Pfam; PF14041; Lipoprotein_21; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..202
FT                   /note="Putative lipoprotein LprE"
FT                   /id="PRO_0000018141"
FT   REGION          29..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..65
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           29
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   LIPID           29
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   202 AA;  20442 MW;  E3DCE415A91DAAFE CRC64;
     MPGVWSPPCP TTPRVGVVAA LVAATLTGCG SGDSTVAKTP EATPSLSTAH PAPPSSEPSP
     PSATAAPPSN HSAAPVDPCA VNLASPTIAK VVSELPRDPR SEQPWNPEPL AGNYNECAQL
     SAVVIKANTN AGNPTTRAVM FHLGKYIPQG VPDTYGFTGI DTSQCTGDTV ALTYASGIGL
     NNVVKFRWNG GGVELIGNTT GG