ID   LPRM_ENTFL              Reviewed;          27 AA.
AC   P23130;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2003, sequence version 2.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=23S rRNA methylase leader peptide;
DE   AltName: Full=Erythromycin resistance leader peptide;
GN   Name=ermC;
OS   Enterococcus faecalis (Streptococcus faecalis).
OG   Plasmid pAD2.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=1351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DS16; PLASMID=pAD2; TRANSPOSON=Tn917;
RX   PubMed=2997130; DOI=10.1128/jb.164.2.782-796.1985;
RA   Shaw J.H., Clewell D.B.;
RT   "Complete nucleotide sequence of macrolide-lincosamide-streptogramin B-
RT   resistance transposon Tn917 in Streptococcus faecalis.";
RL   J. Bacteriol. 164:782-796(1985).
RN   [2]
RP   SEQUENCE REVISION TO C-TERMINUS.
RA   Flannagan S.E., Clewell D.B.;
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This peptide is involved in the control mechanism of the
CC       synthesis of the erythromycin resistance protein.
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DR   EMBL; M11180; AAA27451.2; -; Genomic_DNA.
DR   PIR; A25028; A25028.
DR   RefSeq; WP_001814874.1; NZ_WYAC01000004.1.
DR   RefSeq; YP_004032992.1; NC_014726.1.
DR   RefSeq; YP_004033001.1; NC_014726.1.
DR   RefSeq; YP_783897.1; NC_008445.1.
DR   AlphaFoldDB; P23130; -.
DR   GeneID; 61910860; -.
DR   GeneID; 64019359; -.
DR   GeneID; 67412457; -.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR009391; ErmCL.
DR   Pfam; PF06308; ErmC; 1.
PE   4: Predicted;
KW   Antibiotic resistance; Leader peptide; Plasmid; Transposable element.
FT   PEPTIDE         1..27
FT                   /note="23S rRNA methylase leader peptide"
FT                   /id="PRO_0000044004"
SQ   SEQUENCE   27 AA;  3162 MW;  3EAAD5666D78CD2E CRC64;
     MLVFQMRNVD KTSTVLKQTK NSDYADK