ID   LPRM_STAAU              Reviewed;          19 AA.
AC   P03063;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=23S rRNA methylase leader peptide;
DE   AltName: Full=Erythromycin resistance leader peptide;
GN   Name=ermC;
OS   Staphylococcus aureus.
OG   Plasmid pE194, and Plasmid pT48.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pE194;
RX   PubMed=6162157; DOI=10.1093/nar/8.24.6081;
RA   Gryczan T.J., Grandi G., Hahn J., Grandi R., Dubnau D.;
RT   "Conformational alteration of mRNA structure and the posttranscriptional
RT   regulation of erythromycin-induced drug resistance.";
RL   Nucleic Acids Res. 8:6081-6097(1980).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pE194;
RX   PubMed=6938954; DOI=10.1073/pnas.77.12.7079;
RA   Horinouchi S., Weisblum B.;
RT   "Posttranscriptional modification of mRNA conformation: mechanism that
RT   regulates erythromycin-induced resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:7079-7083(1980).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pE194;
RX   PubMed=2414456; DOI=10.1016/0022-2836(85)90061-0;
RA   Mayford M., Weisblum B.;
RT   "Messenger RNA from Staphylococcus aureus that specifies macrolide-
RT   lincosamide-streptogramin resistance. Demonstration of its conformations
RT   and of the leader peptide it encodes.";
RL   J. Mol. Biol. 185:769-780(1985).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pE194;
RX   PubMed=2467989; DOI=10.1016/0022-2836(89)90524-x;
RA   Mayford M., Weisblum B.;
RT   "ermC leader peptide. Amino acid sequence critical for induction by
RT   translational attenuation.";
RL   J. Mol. Biol. 206:69-79(1989).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pT48;
RX   PubMed=3141573; DOI=10.1099/00221287-134-3-697;
RA   Catchpole I., Thomas C., Davies A., Dyke K.G.H.;
RT   "The nucleotide sequence of Staphylococcus aureus plasmid pT48 conferring
RT   inducible macrolide-lincosamide-streptogramin B resistance and comparison
RT   with similar plasmids expressing constitutive resistance.";
RL   J. Gen. Microbiol. 134:697-709(1988).
CC   -!- FUNCTION: This peptide is involved in the control mechanism of the
CC       synthesis of the erythromycin resistance protein.
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DR   EMBL; V01278; CAA24592.1; -; Genomic_DNA.
DR   EMBL; M37841; AAA98225.1; -; Genomic_DNA.
DR   EMBL; M19652; AAA20193.1; -; Unassigned_DNA.
DR   PIR; B93717; LFSAP9.
DR   RefSeq; WP_002497446.1; NZ_WNWJ01000023.1.
DR   RefSeq; YP_009060499.1; NC_024963.1.
DR   PDB; 3J7Z; EM; 3.90 A; a=1-19.
DR   PDBsum; 3J7Z; -.
DR   AlphaFoldDB; P03063; -.
DR   SMR; P03063; -.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR013204; Leader_Erm.
DR   Pfam; PF08253; Leader_Erm; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic resistance; Leader peptide; Plasmid.
FT   PEPTIDE         1..19
FT                   /note="23S rRNA methylase leader peptide"
FT                   /id="PRO_0000044005"
SQ   SEQUENCE   19 AA;  2210 MW;  13FEE3D99E4F3A7B CRC64;
     MGIFSIFVIS TVHYQPNKK