ID   LPSC_RHIME              Reviewed;         270 AA.
AC   Q9R9M9;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Lipopolysaccharide core biosynthesis glycosyltransferase LpsC;
DE            EC=2.4.-.-;
GN   Name=lpsC; OrderedLocusNames=R01569; ORFNames=SMc01222;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RCR2011 / SU47;
RX   PubMed=11157937; DOI=10.1128/jb.183.4.1248-1258.2001;
RA   Lagares A., Hozbor D.F., Niehaus K., Pich Otero A.J.L., Lorenzen J.,
RA   Arnold W., Puehler A.;
RT   "Genetic characterization of a Sinorhizobium meliloti chromosomal region
RT   involved in lipopolysaccharide biosynthesis.";
RL   J. Bacteriol. 183:1248-1258(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. WaaE/KdtX
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF06011.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF193023; AAF06011.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL591688; CAC46148.1; -; Genomic_DNA.
DR   RefSeq; NP_385675.1; NC_003047.1.
DR   RefSeq; WP_010969309.1; NC_003047.1.
DR   AlphaFoldDB; Q9R9M9; -.
DR   SMR; Q9R9M9; -.
DR   STRING; 266834.SMc01222; -.
DR   CAZy; GT2; Glycosyltransferase Family 2.
DR   EnsemblBacteria; CAC46148; CAC46148; SMc01222.
DR   GeneID; 61603031; -.
DR   KEGG; sme:SMc01222; -.
DR   PATRIC; fig|266834.11.peg.2995; -.
DR   eggNOG; COG0463; Bacteria.
DR   HOGENOM; CLU_065962_1_0_5; -.
DR   OMA; YTELWAL; -.
DR   UniPathway; UPA00958; -.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR001173; Glyco_trans_2-like.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00535; Glycos_transf_2; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Lipopolysaccharide biosynthesis; Reference proteome;
KW   Transferase.
FT   CHAIN           1..270
FT                   /note="Lipopolysaccharide core biosynthesis
FT                   glycosyltransferase LpsC"
FT                   /id="PRO_0000059221"
FT   CONFLICT        257..270
FT                   /note="ALKARPNVDDALSH -> VSEGAPECG (in Ref. 1; AAF06011)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   270 AA;  30899 MW;  90F576AD443293F9 CRC64;
     MIPKLPLSAF IICLNEEAYL GKCIESLERC AEIVIVDSGS TDGTAALVQS YIDAGWPIRF
     MYEPWRGYAG QKQFALEQCS QPWCFNIDAD ERLDKALREL LPELLAASDE IVGWRVARRP
     YLIGYGYTPE NVRERRNLRL IRRGKGRYDL SQKVHEGIVP EGNVGNARTG SLLHFRPLVM
     DEQILKENKY STLKADQQVE SGKRPRFYKL IFTPPIYFLR LYFRNGLWRC GLSGFIEAMT
     GAVYAFLTAA KIYQRHALKA RPNVDDALSH