ID   LPTA_ECO57              Reviewed;         185 AA.
AC   P0ADV3; P38685;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Lipopolysaccharide export system protein LptA {ECO:0000255|HAMAP-Rule:MF_01914};
DE   Flags: Precursor;
GN   Name=lptA {ECO:0000255|HAMAP-Rule:MF_01914};
GN   OrderedLocusNames=Z4563, ECs4079;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Involved in the assembly of lipopolysaccharide (LPS).
CC       Required for the translocation of LPS from the inner membrane to the
CC       outer membrane. May form a bridge between the inner membrane and the
CC       outer membrane, via interactions with LptC and LptD, thereby
CC       facilitating LPS transfer across the periplasm. {ECO:0000255|HAMAP-
CC       Rule:MF_01914}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. {ECO:0000255|HAMAP-Rule:MF_01914}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_01914}.
CC   -!- SIMILARITY: Belongs to the LptA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01914}.
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DR   EMBL; AE005174; AAG58334.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37502.1; -; Genomic_DNA.
DR   PIR; B85984; B85984.
DR   PIR; G91138; G91138.
DR   RefSeq; NP_312106.1; NC_002695.1.
DR   RefSeq; WP_000669785.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0ADV3; -.
DR   SMR; P0ADV3; -.
DR   STRING; 155864.EDL933_4428; -.
DR   EnsemblBacteria; AAG58334; AAG58334; Z4563.
DR   EnsemblBacteria; BAB37502; BAB37502; ECs_4079.
DR   GeneID; 67415966; -.
DR   GeneID; 916075; -.
DR   KEGG; ece:Z4563; -.
DR   KEGG; ecs:ECs_4079; -.
DR   PATRIC; fig|386585.9.peg.4258; -.
DR   eggNOG; COG1934; Bacteria.
DR   HOGENOM; CLU_095993_2_1_6; -.
DR   OMA; VPTQQME; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IEA:InterPro.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01914; LPS_assembly_LptA; 1.
DR   InterPro; IPR014340; LptA.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF03968; LptD_N; 1.
DR   TIGRFAMs; TIGR03002; outer_YhbN_LptA; 1.
PE   3: Inferred from homology;
KW   Periplasm; Reference proteome; Signal; Transport.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01914"
FT   CHAIN           28..185
FT                   /note="Lipopolysaccharide export system protein LptA"
FT                   /id="PRO_0000043109"
FT   REGION          166..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   185 AA;  20127 MW;  BA69198479C68DC1 CRC64;
     MKFKTNKLSL NLVLASSLLA ASIPAFAVTG DTDQPIHIES DQQSLDMQGN VVTFTGNVIV
     TQGTIKINAD KVVVTRPGGE QGKEVIDGYG KPATFYQMQD NGKPVEGHAS QMHYELAKDF
     VVLTGNAYLQ QVDSNIKGDK ITYLVKEQKM QAFSDKGKRV TTVLVPSQLQ DKNNKGQTPA
     QKKGN