LPTA_ECOL6
ID LPTA_ECOL6 Reviewed; 185 AA.
AC P0ADV2; P38685;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Lipopolysaccharide export system protein LptA {ECO:0000255|HAMAP-Rule:MF_01914};
DE Flags: Precursor;
GN Name=lptA {ECO:0000255|HAMAP-Rule:MF_01914}; OrderedLocusNames=c3960;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Involved in the assembly of lipopolysaccharide (LPS).
CC Required for the translocation of LPS from the inner membrane to the
CC outer membrane. May form a bridge between the inner membrane and the
CC outer membrane, via interactions with LptC and LptD, thereby
CC facilitating LPS transfer across the periplasm. {ECO:0000255|HAMAP-
CC Rule:MF_01914}.
CC -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC complex. {ECO:0000255|HAMAP-Rule:MF_01914}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_01914}.
CC -!- SIMILARITY: Belongs to the LptA family. {ECO:0000255|HAMAP-
CC Rule:MF_01914}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN82400.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014075; AAN82400.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_000669785.1; NC_004431.1.
DR AlphaFoldDB; P0ADV2; -.
DR SMR; P0ADV2; -.
DR STRING; 199310.c3960; -.
DR EnsemblBacteria; AAN82400; AAN82400; c3960.
DR GeneID; 67415966; -.
DR KEGG; ecc:c3960; -.
DR eggNOG; COG1934; Bacteria.
DR HOGENOM; CLU_095993_2_1_6; -.
DR OMA; VPTQQME; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0001530; F:lipopolysaccharide binding; IEA:InterPro.
DR GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0015920; P:lipopolysaccharide transport; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01914; LPS_assembly_LptA; 1.
DR InterPro; IPR014340; LptA.
DR InterPro; IPR005653; OstA-like_N.
DR Pfam; PF03968; LptD_N; 1.
DR TIGRFAMs; TIGR03002; outer_YhbN_LptA; 1.
PE 3: Inferred from homology;
KW Periplasm; Signal; Transport.
FT SIGNAL 1..27
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01914"
FT CHAIN 28..185
FT /note="Lipopolysaccharide export system protein LptA"
FT /id="PRO_0000043110"
FT REGION 166..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 185 AA; 20127 MW; BA69198479C68DC1 CRC64;
MKFKTNKLSL NLVLASSLLA ASIPAFAVTG DTDQPIHIES DQQSLDMQGN VVTFTGNVIV
TQGTIKINAD KVVVTRPGGE QGKEVIDGYG KPATFYQMQD NGKPVEGHAS QMHYELAKDF
VVLTGNAYLQ QVDSNIKGDK ITYLVKEQKM QAFSDKGKRV TTVLVPSQLQ DKNNKGQTPA
QKKGN