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LPTA_ECOL6
ID   LPTA_ECOL6              Reviewed;         185 AA.
AC   P0ADV2; P38685;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Lipopolysaccharide export system protein LptA {ECO:0000255|HAMAP-Rule:MF_01914};
DE   Flags: Precursor;
GN   Name=lptA {ECO:0000255|HAMAP-Rule:MF_01914}; OrderedLocusNames=c3960;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Involved in the assembly of lipopolysaccharide (LPS).
CC       Required for the translocation of LPS from the inner membrane to the
CC       outer membrane. May form a bridge between the inner membrane and the
CC       outer membrane, via interactions with LptC and LptD, thereby
CC       facilitating LPS transfer across the periplasm. {ECO:0000255|HAMAP-
CC       Rule:MF_01914}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. {ECO:0000255|HAMAP-Rule:MF_01914}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_01914}.
CC   -!- SIMILARITY: Belongs to the LptA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01914}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN82400.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN82400.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000669785.1; NC_004431.1.
DR   AlphaFoldDB; P0ADV2; -.
DR   SMR; P0ADV2; -.
DR   STRING; 199310.c3960; -.
DR   EnsemblBacteria; AAN82400; AAN82400; c3960.
DR   GeneID; 67415966; -.
DR   KEGG; ecc:c3960; -.
DR   eggNOG; COG1934; Bacteria.
DR   HOGENOM; CLU_095993_2_1_6; -.
DR   OMA; VPTQQME; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IEA:InterPro.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01914; LPS_assembly_LptA; 1.
DR   InterPro; IPR014340; LptA.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF03968; LptD_N; 1.
DR   TIGRFAMs; TIGR03002; outer_YhbN_LptA; 1.
PE   3: Inferred from homology;
KW   Periplasm; Signal; Transport.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01914"
FT   CHAIN           28..185
FT                   /note="Lipopolysaccharide export system protein LptA"
FT                   /id="PRO_0000043110"
FT   REGION          166..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   185 AA;  20127 MW;  BA69198479C68DC1 CRC64;
     MKFKTNKLSL NLVLASSLLA ASIPAFAVTG DTDQPIHIES DQQSLDMQGN VVTFTGNVIV
     TQGTIKINAD KVVVTRPGGE QGKEVIDGYG KPATFYQMQD NGKPVEGHAS QMHYELAKDF
     VVLTGNAYLQ QVDSNIKGDK ITYLVKEQKM QAFSDKGKRV TTVLVPSQLQ DKNNKGQTPA
     QKKGN
 
 
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