ID   LPTA_HAEIN              Reviewed;         172 AA.
AC   P45074;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Lipopolysaccharide export system protein LptA {ECO:0000255|HAMAP-Rule:MF_01914};
DE   Flags: Precursor;
GN   Name=lptA {ECO:0000255|HAMAP-Rule:MF_01914}; OrderedLocusNames=HI_1149;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA   Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- FUNCTION: Involved in the assembly of lipopolysaccharide (LPS).
CC       Required for the translocation of LPS from the inner membrane to the
CC       outer membrane. May form a bridge between the inner membrane and the
CC       outer membrane, via interactions with LptC and LptD, thereby
CC       facilitating LPS transfer across the periplasm. {ECO:0000255|HAMAP-
CC       Rule:MF_01914}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. {ECO:0000255|HAMAP-Rule:MF_01914}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_01914}.
CC   -!- SIMILARITY: Belongs to the LptA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01914}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC22804.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L42023; AAC22804.1; ALT_INIT; Genomic_DNA.
DR   PIR; A64168; A64168.
DR   RefSeq; NP_439307.1; NC_000907.1.
DR   RefSeq; WP_005693464.1; NC_000907.1.
DR   AlphaFoldDB; P45074; -.
DR   SMR; P45074; -.
DR   STRING; 71421.HI_1149; -.
DR   EnsemblBacteria; AAC22804; AAC22804; HI_1149.
DR   KEGG; hin:HI_1149; -.
DR   PATRIC; fig|71421.8.peg.1199; -.
DR   eggNOG; COG1934; Bacteria.
DR   HOGENOM; CLU_095993_2_0_6; -.
DR   PhylomeDB; P45074; -.
DR   BioCyc; HINF71421:G1GJ1-1182-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IBA:GO_Central.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IBA:GO_Central.
DR   GO; GO:0017089; F:glycolipid transfer activity; IBA:GO_Central.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IEA:InterPro.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IBA:GO_Central.
DR   HAMAP; MF_01914; LPS_assembly_LptA; 1.
DR   InterPro; IPR014340; LptA.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF03968; LptD_N; 1.
DR   TIGRFAMs; TIGR03002; outer_YhbN_LptA; 1.
PE   1: Evidence at protein level;
KW   Periplasm; Reference proteome; Signal; Transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01914"
FT   CHAIN           24..172
FT                   /note="Lipopolysaccharide export system protein LptA"
FT                   /id="PRO_0000013915"
SQ   SEQUENCE   172 AA;  18700 MW;  2877F89B3D7F351E CRC64;
     MKLVSNKILF LATMVLASSS AFALKDDVNQ PINIVSDNQS LDMEKSVVTF TDNVVITQGS
     IVIKANKVVI TRPAEKSGKK ETVEAFGTPV TFHQQLDNGK PVDGKANKVH YDLGNEFLTL
     TNNAELKQLD SKINGSVITY DVKKQQLKAN GNGKSRVTTV LIPSQLQQAK GK