ID   LPTA_SHIFL              Reviewed;         185 AA.
AC   P0ADV4; P38685;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Lipopolysaccharide export system protein LptA {ECO:0000255|HAMAP-Rule:MF_01914};
DE   Flags: Precursor;
GN   Name=lptA {ECO:0000255|HAMAP-Rule:MF_01914};
GN   OrderedLocusNames=SF3240, S3458;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Involved in the assembly of lipopolysaccharide (LPS).
CC       Required for the translocation of LPS from the inner membrane to the
CC       outer membrane. May form a bridge between the inner membrane and the
CC       outer membrane, via interactions with LptC and LptD, thereby
CC       facilitating LPS transfer across the periplasm. {ECO:0000255|HAMAP-
CC       Rule:MF_01914}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. {ECO:0000255|HAMAP-Rule:MF_01914}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_01914}.
CC   -!- SIMILARITY: Belongs to the LptA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01914}.
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DR   EMBL; AE005674; AAN44706.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18520.1; -; Genomic_DNA.
DR   RefSeq; NP_708999.2; NC_004337.2.
DR   RefSeq; WP_000669785.1; NZ_WPGW01000004.1.
DR   AlphaFoldDB; P0ADV4; -.
DR   SMR; P0ADV4; -.
DR   STRING; 198214.SF3240; -.
DR   EnsemblBacteria; AAN44706; AAN44706; SF3240.
DR   EnsemblBacteria; AAP18520; AAP18520; S3458.
DR   GeneID; 1027131; -.
DR   GeneID; 67415966; -.
DR   KEGG; sfl:SF3240; -.
DR   KEGG; sfx:S3458; -.
DR   PATRIC; fig|198214.7.peg.3841; -.
DR   HOGENOM; CLU_095993_2_1_6; -.
DR   OrthoDB; 1696422at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IEA:InterPro.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01914; LPS_assembly_LptA; 1.
DR   InterPro; IPR014340; LptA.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF03968; LptD_N; 1.
DR   TIGRFAMs; TIGR03002; outer_YhbN_LptA; 1.
PE   3: Inferred from homology;
KW   Periplasm; Reference proteome; Signal; Transport.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01914"
FT   CHAIN           28..185
FT                   /note="Lipopolysaccharide export system protein LptA"
FT                   /id="PRO_0000043111"
FT   REGION          166..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   185 AA;  20127 MW;  BA69198479C68DC1 CRC64;
     MKFKTNKLSL NLVLASSLLA ASIPAFAVTG DTDQPIHIES DQQSLDMQGN VVTFTGNVIV
     TQGTIKINAD KVVVTRPGGE QGKEVIDGYG KPATFYQMQD NGKPVEGHAS QMHYELAKDF
     VVLTGNAYLQ QVDSNIKGDK ITYLVKEQKM QAFSDKGKRV TTVLVPSQLQ DKNNKGQTPA
     QKKGN