LPTB_HAEIN
ID LPTB_HAEIN Reviewed; 241 AA.
AC P45073;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Lipopolysaccharide export system ATP-binding protein LptB;
DE EC=7.5.2.-;
GN Name=lptB; OrderedLocusNames=HI_1148;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=10675023;
RX DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA Fountoulakis M.;
RT "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL Electrophoresis 21:411-429(2000).
CC -!- FUNCTION: Part of the ABC transporter complex LptBFG involved in the
CC translocation of lipopolysaccharide (LPS) from the inner membrane to
CC the outer membrane. Probably responsible for energy coupling to the
CC transport system (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC complex. The LptBFG transporter is composed of two ATP-binding proteins
CC (LptB) and two transmembrane proteins (LptF and LptG) (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cell inner membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Outer membrane
CC lipopolysaccharide export (TC 1.B.42) family. {ECO:0000305}.
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DR EMBL; L42023; AAC22803.1; -; Genomic_DNA.
DR PIR; I64167; I64167.
DR RefSeq; NP_439306.1; NC_000907.1.
DR RefSeq; WP_005647567.1; NC_000907.1.
DR AlphaFoldDB; P45073; -.
DR SMR; P45073; -.
DR STRING; 71421.HI_1148; -.
DR EnsemblBacteria; AAC22803; AAC22803; HI_1148.
DR KEGG; hin:HI_1148; -.
DR PATRIC; fig|71421.8.peg.1198; -.
DR eggNOG; COG1137; Bacteria.
DR HOGENOM; CLU_000604_1_2_6; -.
DR OMA; LPMYQRA; -.
DR PhylomeDB; P45073; -.
DR BioCyc; HINF71421:G1GJ1-1181-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd03218; ABC_YhbG; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR032823; BCA_ABC_TP_C.
DR InterPro; IPR030921; LPS_export_LptB.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF12399; BCA_ABC_TP_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR04406; LPS_export_lptB; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell inner membrane; Cell membrane; Cytoplasm; Membrane;
KW Nucleotide-binding; Reference proteome; Translocase; Transport.
FT CHAIN 1..241
FT /note="Lipopolysaccharide export system ATP-binding protein
FT LptB"
FT /id="PRO_0000093182"
FT DOMAIN 4..237
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 36..43
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 241 AA; 26814 MW; 7C46F4DE42CBB321 CRC64;
MSILTAENLA KSYKSRKVVS DVSLTVNSNE IVGLLGPNGA GKTTTFYMVV GLVRQDQGKI
VIDGEDISLL PMHNRAQRGI GYLPQEASIF RRLTVYENLM AVLEIRKDLT PQQRREKADE
LIEEFNISHI RDNLGQALSG GERRRVEIAR ALAANPKFIL LDEPFAGVDP ISVSDIKKII
TDLRNRGLGV LITDHNVRET LDVCERAYIV GAGKIIATGT PEQVMNDEQV KRVYLGEQFK
L
