LPTB_SHIFL
ID LPTB_SHIFL Reviewed; 241 AA.
AC P0A9V4; P31220;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Lipopolysaccharide export system ATP-binding protein LptB;
DE EC=7.5.2.-;
GN Name=lptB; OrderedLocusNames=SF3241, S3459;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Part of the ABC transporter complex LptBFG involved in the
CC translocation of lipopolysaccharide (LPS) from the inner membrane to
CC the outer membrane. Probably responsible for energy coupling to the
CC transport system (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC complex. The LptBFG transporter is composed of two ATP-binding proteins
CC (LptB) and two transmembrane proteins (LptF and LptG) (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cell inner membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Outer membrane
CC lipopolysaccharide export (TC 1.B.42) family. {ECO:0000305}.
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DR EMBL; AE005674; AAN44707.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP18521.1; -; Genomic_DNA.
DR RefSeq; NP_709000.1; NC_004337.2.
DR RefSeq; WP_000224099.1; NZ_WPGW01000004.1.
DR PDB; 6S8G; EM; 3.50 A; A/B=1-241.
DR PDB; 6S8H; EM; 3.70 A; A/B=1-241.
DR PDB; 6S8N; EM; 3.10 A; A/B=1-241.
DR PDBsum; 6S8G; -.
DR PDBsum; 6S8H; -.
DR PDBsum; 6S8N; -.
DR AlphaFoldDB; P0A9V4; -.
DR SMR; P0A9V4; -.
DR STRING; 198214.SF3241; -.
DR PRIDE; P0A9V4; -.
DR EnsemblBacteria; AAN44707; AAN44707; SF3241.
DR EnsemblBacteria; AAP18521; AAP18521; S3459.
DR GeneID; 1027080; -.
DR GeneID; 67415965; -.
DR KEGG; sfl:SF3241; -.
DR KEGG; sfx:S3459; -.
DR PATRIC; fig|198214.7.peg.3842; -.
DR HOGENOM; CLU_000604_1_2_6; -.
DR OMA; LPMYQRA; -.
DR OrthoDB; 1220708at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd03218; ABC_YhbG; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR032823; BCA_ABC_TP_C.
DR InterPro; IPR030921; LPS_export_LptB.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF12399; BCA_ABC_TP_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR04406; LPS_export_lptB; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Cell inner membrane; Cell membrane; Cytoplasm;
KW Membrane; Nucleotide-binding; Reference proteome; Translocase; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..241
FT /note="Lipopolysaccharide export system ATP-binding protein
FT LptB"
FT /id="PRO_0000093181"
FT DOMAIN 4..237
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 36..43
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT STRAND 3..5
FT /evidence="ECO:0007829|PDB:6S8N"
FT STRAND 8..22
FT /evidence="ECO:0007829|PDB:6S8N"
FT STRAND 25..29
FT /evidence="ECO:0007829|PDB:6S8N"
FT STRAND 31..33
FT /evidence="ECO:0007829|PDB:6S8N"
FT STRAND 38..40
FT /evidence="ECO:0007829|PDB:6S8G"
FT HELIX 44..50
FT /evidence="ECO:0007829|PDB:6S8N"
FT STRAND 51..53
FT /evidence="ECO:0007829|PDB:6S8N"
FT STRAND 59..62
FT /evidence="ECO:0007829|PDB:6S8G"
FT HELIX 72..75
FT /evidence="ECO:0007829|PDB:6S8N"
FT TURN 76..79
FT /evidence="ECO:0007829|PDB:6S8N"
FT STRAND 80..83
FT /evidence="ECO:0007829|PDB:6S8N"
FT STRAND 91..93
FT /evidence="ECO:0007829|PDB:6S8G"
FT HELIX 95..103
FT /evidence="ECO:0007829|PDB:6S8N"
FT TURN 111..113
FT /evidence="ECO:0007829|PDB:6S8N"
FT TURN 115..117
FT /evidence="ECO:0007829|PDB:6S8N"
FT HELIX 118..124
FT /evidence="ECO:0007829|PDB:6S8N"
FT HELIX 128..130
FT /evidence="ECO:0007829|PDB:6S8G"
FT STRAND 140..142
FT /evidence="ECO:0007829|PDB:6S8N"
FT TURN 143..145
FT /evidence="ECO:0007829|PDB:6S8N"
FT HELIX 146..152
FT /evidence="ECO:0007829|PDB:6S8N"
FT STRAND 157..167
FT /evidence="ECO:0007829|PDB:6S8N"
FT HELIX 173..185
FT /evidence="ECO:0007829|PDB:6S8N"
FT STRAND 190..192
FT /evidence="ECO:0007829|PDB:6S8N"
FT TURN 200..202
FT /evidence="ECO:0007829|PDB:6S8N"
FT STRAND 205..207
FT /evidence="ECO:0007829|PDB:6S8N"
FT STRAND 209..211
FT /evidence="ECO:0007829|PDB:6S8N"
FT STRAND 214..217
FT /evidence="ECO:0007829|PDB:6S8N"
FT HELIX 221..224
FT /evidence="ECO:0007829|PDB:6S8N"
FT HELIX 230..233
FT /evidence="ECO:0007829|PDB:6S8N"
SQ SEQUENCE 241 AA; 26801 MW; 6041495BDDCDFA72 CRC64;
MATLTAKNLA KAYKGRRVVE DVSLTVNSGE IVGLLGPNGA GKTTTFYMVV GIVPRDAGNI
IIDDDDISLL PLHARARRGI GYLPQEASIF RRLSVYDNLM AVLQIRDDLS AEQREDRANE
LMEEFHIEHL RDSMGQSLSG GERRRVEIAR ALAANPKFIL LDEPFAGVDP ISVIDIKRII
EHLRDSGLGV LITDHNVRET LAVCERAYIV SQGHLIAHGT PTEILQDEHV KRVYLGEDFR
L
