ID   LPTC_ECO57              Reviewed;         191 AA.
AC   P0ADW1; P45397;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Lipopolysaccharide export system protein LptC {ECO:0000255|HAMAP-Rule:MF_01915};
GN   Name=lptC {ECO:0000255|HAMAP-Rule:MF_01915};
GN   OrderedLocusNames=Z4562, ECs4078;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Involved in the assembly of lipopolysaccharide (LPS).
CC       Required for the translocation of LPS from the inner membrane to the
CC       outer membrane. Facilitates the transfer of LPS from the inner membrane
CC       to the periplasmic protein LptA. Could be a docking site for LptA.
CC       {ECO:0000255|HAMAP-Rule:MF_01915}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptA and the LptBFG transporter complex.
CC       {ECO:0000255|HAMAP-Rule:MF_01915}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01915}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01915}.
CC   -!- SIMILARITY: Belongs to the LptC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01915}.
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DR   EMBL; AE005174; AAG58333.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37501.1; -; Genomic_DNA.
DR   PIR; A85984; A85984.
DR   PIR; F91138; F91138.
DR   RefSeq; NP_312105.1; NC_002695.1.
DR   RefSeq; WP_000030537.1; NZ_SEKU01000004.1.
DR   AlphaFoldDB; P0ADW1; -.
DR   SMR; P0ADW1; -.
DR   STRING; 155864.EDL933_4427; -.
DR   EnsemblBacteria; AAG58333; AAG58333; Z4562.
DR   EnsemblBacteria; BAB37501; BAB37501; ECs_4078.
DR   GeneID; 66672899; -.
DR   GeneID; 916076; -.
DR   KEGG; ece:Z4562; -.
DR   KEGG; ecs:ECs_4078; -.
DR   PATRIC; fig|386585.9.peg.4257; -.
DR   eggNOG; COG3117; Bacteria.
DR   HOGENOM; CLU_105814_2_1_6; -.
DR   OMA; YWQVQSK; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0015221; F:lipopolysaccharide transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01915; LPS_assembly_LptC; 1.
DR   InterPro; IPR010664; LipoPS_assembly_LptC-rel.
DR   InterPro; IPR026265; LptC.
DR   Pfam; PF06835; LptC; 1.
DR   PIRSF; PIRSF028513; LptC; 1.
DR   TIGRFAMs; TIGR04409; LptC_YrbK; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..191
FT                   /note="Lipopolysaccharide export system protein LptC"
FT                   /id="PRO_0000169471"
FT   TRANSMEM        7..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01915"
SQ   SEQUENCE   191 AA;  21703 MW;  F6BAE79EA232CD95 CRC64;
     MSKARRWVII VLSLAVLVMI GINMAEKDDT AQVVVNNNDP TYKSEHTDTL VYNPEGALSY
     RLIAQHVEYY SDQAVSWFTQ PVLTTFDKDK IPTWSVKADK AKLTNDRMLY LYGHVEVNAL
     VPDSQLRRIT TDNAQINLVT QDVTSEDLVT LYGTTFNSSG LKMRGNLRSK NAELIEKVRT
     SYEIQNKQTQ P