ID   LPTC_ECOL6              Reviewed;         191 AA.
AC   P0ADW0; P45397;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Lipopolysaccharide export system protein LptC {ECO:0000255|HAMAP-Rule:MF_01915};
GN   Name=lptC {ECO:0000255|HAMAP-Rule:MF_01915}; OrderedLocusNames=c3959;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Involved in the assembly of lipopolysaccharide (LPS).
CC       Required for the translocation of LPS from the inner membrane to the
CC       outer membrane. Facilitates the transfer of LPS from the inner membrane
CC       to the periplasmic protein LptA. Could be a docking site for LptA.
CC       {ECO:0000255|HAMAP-Rule:MF_01915}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptA and the LptBFG transporter complex.
CC       {ECO:0000255|HAMAP-Rule:MF_01915}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01915}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01915}.
CC   -!- SIMILARITY: Belongs to the LptC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01915}.
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DR   EMBL; AE014075; AAN82399.1; -; Genomic_DNA.
DR   RefSeq; WP_000030537.1; NC_004431.1.
DR   AlphaFoldDB; P0ADW0; -.
DR   SMR; P0ADW0; -.
DR   STRING; 199310.c3959; -.
DR   TCDB; 1.B.42.1.2; the outer membrane lipopolysaccharide export porin (lps-ep) family.
DR   EnsemblBacteria; AAN82399; AAN82399; c3959.
DR   GeneID; 66672899; -.
DR   KEGG; ecc:c3959; -.
DR   eggNOG; COG3117; Bacteria.
DR   HOGENOM; CLU_105814_2_1_6; -.
DR   OMA; YWQVQSK; -.
DR   BioCyc; ECOL199310:C3959-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0015221; F:lipopolysaccharide transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01915; LPS_assembly_LptC; 1.
DR   InterPro; IPR010664; LipoPS_assembly_LptC-rel.
DR   InterPro; IPR026265; LptC.
DR   Pfam; PF06835; LptC; 1.
DR   PIRSF; PIRSF028513; LptC; 1.
DR   TIGRFAMs; TIGR04409; LptC_YrbK; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..191
FT                   /note="Lipopolysaccharide export system protein LptC"
FT                   /id="PRO_0000169472"
FT   TRANSMEM        7..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01915"
SQ   SEQUENCE   191 AA;  21703 MW;  F6BAE79EA232CD95 CRC64;
     MSKARRWVII VLSLAVLVMI GINMAEKDDT AQVVVNNNDP TYKSEHTDTL VYNPEGALSY
     RLIAQHVEYY SDQAVSWFTQ PVLTTFDKDK IPTWSVKADK AKLTNDRMLY LYGHVEVNAL
     VPDSQLRRIT TDNAQINLVT QDVTSEDLVT LYGTTFNSSG LKMRGNLRSK NAELIEKVRT
     SYEIQNKQTQ P