ID   LPTC_HAEIN              Reviewed;         209 AA.
AC   P45075;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Lipopolysaccharide export system protein LptC {ECO:0000255|HAMAP-Rule:MF_01915};
GN   Name=lptC {ECO:0000255|HAMAP-Rule:MF_01915}; OrderedLocusNames=HI_1150;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Involved in the assembly of lipopolysaccharide (LPS).
CC       Required for the translocation of LPS from the inner membrane to the
CC       outer membrane. Facilitates the transfer of LPS from the inner membrane
CC       to the periplasmic protein LptA. Could be a docking site for LptA.
CC       {ECO:0000255|HAMAP-Rule:MF_01915}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptA and the LptBFG transporter complex.
CC       {ECO:0000255|HAMAP-Rule:MF_01915}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01915}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01915}.
CC   -!- SIMILARITY: Belongs to the LptC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01915}.
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DR   EMBL; L42023; AAC22805.1; -; Genomic_DNA.
DR   PIR; B64168; B64168.
DR   RefSeq; NP_439308.2; NC_000907.1.
DR   AlphaFoldDB; P45075; -.
DR   SMR; P45075; -.
DR   STRING; 71421.HI_1150; -.
DR   EnsemblBacteria; AAC22805; AAC22805; HI_1150.
DR   KEGG; hin:HI_1150; -.
DR   PATRIC; fig|71421.8.peg.1200; -.
DR   eggNOG; COG3117; Bacteria.
DR   HOGENOM; CLU_105814_2_0_6; -.
DR   OMA; YWQVQSK; -.
DR   PhylomeDB; P45075; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IBA:GO_Central.
DR   GO; GO:0017089; F:glycolipid transfer activity; IBA:GO_Central.
DR   GO; GO:0015221; F:lipopolysaccharide transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IBA:GO_Central.
DR   HAMAP; MF_01915; LPS_assembly_LptC; 1.
DR   InterPro; IPR010664; LipoPS_assembly_LptC-rel.
DR   InterPro; IPR026265; LptC.
DR   Pfam; PF06835; LptC; 1.
DR   PIRSF; PIRSF028513; LptC; 1.
DR   TIGRFAMs; TIGR04409; LptC_YrbK; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..209
FT                   /note="Lipopolysaccharide export system protein LptC"
FT                   /id="PRO_0000169474"
FT   TRANSMEM        7..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01915"
SQ   SEQUENCE   209 AA;  23819 MW;  589EE98DB0C91133 CRC64;
     MIEIKMNIRW NVILGVIALC ALAWFYSLNQ ETADLSELVK KPDSPDYVGY KMETTVFSPD
     GKKQYLALSD KIEHYTVNEQ TLFTAPLVYL YPTTSNEKEK EKNANQNVDF FSTQSWKLSA
     NQARLTKDQI LYLEGNVVAQ NLTSDSRLQR IETESAVVNL KTQDITSETQ VKIKGKNFSS
     TGLKLVGNLR QQVATLKEQV KTYYEVSKQ