ID   LPTC_SHIFL              Reviewed;         191 AA.
AC   P0ADW2; P45397;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Lipopolysaccharide export system protein LptC {ECO:0000255|HAMAP-Rule:MF_01915};
GN   Name=lptC {ECO:0000255|HAMAP-Rule:MF_01915};
GN   OrderedLocusNames=SF3239, S3457;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Involved in the assembly of lipopolysaccharide (LPS).
CC       Required for the translocation of LPS from the inner membrane to the
CC       outer membrane. Facilitates the transfer of LPS from the inner membrane
CC       to the periplasmic protein LptA. Could be a docking site for LptA.
CC       {ECO:0000255|HAMAP-Rule:MF_01915}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptA and the LptBFG transporter complex.
CC       {ECO:0000255|HAMAP-Rule:MF_01915}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01915}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01915}.
CC   -!- SIMILARITY: Belongs to the LptC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01915}.
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DR   EMBL; AE005674; AAN44705.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18519.1; -; Genomic_DNA.
DR   RefSeq; NP_708998.1; NC_004337.2.
DR   RefSeq; WP_000030537.1; NZ_WPGW01000004.1.
DR   PDB; 6S8N; EM; 3.10 A; C=1-191.
DR   PDBsum; 6S8N; -.
DR   AlphaFoldDB; P0ADW2; -.
DR   SMR; P0ADW2; -.
DR   STRING; 198214.SF3239; -.
DR   EnsemblBacteria; AAN44705; AAN44705; SF3239.
DR   EnsemblBacteria; AAP18519; AAP18519; S3457.
DR   GeneID; 1027116; -.
DR   GeneID; 66672899; -.
DR   KEGG; sfl:SF3239; -.
DR   KEGG; sfx:S3457; -.
DR   PATRIC; fig|198214.7.peg.3840; -.
DR   HOGENOM; CLU_105814_2_1_6; -.
DR   OMA; YWQVQSK; -.
DR   OrthoDB; 1983716at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0015221; F:lipopolysaccharide transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01915; LPS_assembly_LptC; 1.
DR   InterPro; IPR010664; LipoPS_assembly_LptC-rel.
DR   InterPro; IPR026265; LptC.
DR   Pfam; PF06835; LptC; 1.
DR   PIRSF; PIRSF028513; LptC; 1.
DR   TIGRFAMs; TIGR04409; LptC_YrbK; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..191
FT                   /note="Lipopolysaccharide export system protein LptC"
FT                   /id="PRO_0000169473"
FT   TRANSMEM        7..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01915"
FT   HELIX           6..22
FT                   /evidence="ECO:0007829|PDB:6S8N"
SQ   SEQUENCE   191 AA;  21703 MW;  F6BAE79EA232CD95 CRC64;
     MSKARRWVII VLSLAVLVMI GINMAEKDDT AQVVVNNNDP TYKSEHTDTL VYNPEGALSY
     RLIAQHVEYY SDQAVSWFTQ PVLTTFDKDK IPTWSVKADK AKLTNDRMLY LYGHVEVNAL
     VPDSQLRRIT TDNAQINLVT QDVTSEDLVT LYGTTFNSSG LKMRGNLRSK NAELIEKVRT
     SYEIQNKQTQ P