ID   LPTD_COXBU              Reviewed;         870 AA.
AC   Q83AC6;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=CBU_1978;
OS   Coxiella burnetii (strain RSA 493 / Nine Mile phase I).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC   Coxiella.
OX   NCBI_TaxID=227377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RSA 493 / Nine Mile phase I;
RX   PubMed=12704232; DOI=10.1073/pnas.0931379100;
RA   Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C.,
RA   Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T.,
RA   Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M.,
RA   Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E.,
RA   Fraser C.M., Heidelberg J.F.;
RT   "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016828; AAO91467.1; -; Genomic_DNA.
DR   RefSeq; NP_820953.1; NC_002971.3.
DR   RefSeq; WP_005772437.1; NZ_CCYB01000065.1.
DR   AlphaFoldDB; Q83AC6; -.
DR   SMR; Q83AC6; -.
DR   STRING; 227377.CBU_1978; -.
DR   EnsemblBacteria; AAO91467; AAO91467; CBU_1978.
DR   GeneID; 1209891; -.
DR   KEGG; cbu:CBU_1978; -.
DR   PATRIC; fig|227377.7.peg.1966; -.
DR   eggNOG; COG1452; Bacteria.
DR   HOGENOM; CLU_009039_0_0_6; -.
DR   OMA; DYSHLDW; -.
DR   Proteomes; UP000002671; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IBA:GO_Central.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   Pfam; PF04453; LptD; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Reference proteome; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           26..870
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000281600"
SQ   SEQUENCE   870 AA;  99077 MW;  2FD4AC39F0C2DAF8 CRC64;
     MKQGKSFIFY CLVLLLCGFQ QLSSAVTASI AKAIKTTDRK QRVSETLPTG LSYRRFYQHI
     AHLLGWVPAP DLVCRGYFKE PLILTEHPHP GPATKEPAIV TAKGPSMVTA QGVSILRKDV
     VVTQPGRIVE ADKAYIYRDS KTGHVTKIIL IGHVRLHEAD KRIVADKGTL TLYPKTAILM
     NAAYHIYNGE PYFYKFKYPF DAWGIAKHAV RDASNVITLR HATYSTCKPT APAWSMSATT
     LVLNRNTHRG EAYNMLLHIG RVPIFYFPYF NFPIDNYRKT GFLIPYAGHS SSSGWFFALP
     FYWNMAPNYD LTLTPEFMSE RGLNLQSLFR FLSTKSSGTI YLNYLPNDKV FQQFRETTLS
     KFPPSVLAEH PVFIPYVDKL KKMKNQRAFF SMNETTLFNS EWSSRVILNY VTDPYFFQDL
     GGQLGGSSLA NQLLNQIDLQ YNGLHWQFMG MLQAYQTLHL ISQWTTPALD QYSRLPDFNI
     VGYYPDIARH VDFNFNAEAV NFDYRSDFVP DKPRGQRFHM RPGISFPFYF ASGYIIPQLW
     ADATAYNITH FQPGQAHTSS RLLPIFDIDS GLYFDRNFHL GHRSFIQTLE PRFFYLYVPY
     QNQDRFPNFD TVLLPFSFEQ LFALNQFTGN DRLQNANQAS FALTSRVLDA QNGSPILTAN
     VGFIYYLENQ RVCLTPGCTP SNYHYSPIIG ELTFYPFPYW SFTGSLAWDP NLGQTNNTSV
     ELAYNNGGKK ADIRYLFVHG NEDSIVTPTT LIVPGNAYSQ NTNHVISSGA WPLLKKWNAV
     GYWDYNITER RTDVYSIGVQ YNTCCWALSF SIRRTYAGLK VDPNGALQRQ YDTAYGFELQ
     LKGLGNLGTA PISTVTVLDA MNNGVSNDVR