ID   LPTD_CUPMC              Reviewed;         824 AA.
AC   Q1LRA4;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=Rmet_0436;
OS   Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 /
OS   CH34) (Ralstonia metallidurans).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=266264;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34;
RX   PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA   Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N., Michaux A.,
RA   Benotmane M.A., Leys N., Vallaeys T., Lapidus A., Monchy S., Medigue C.,
RA   Taghavi S., McCorkle S., Dunn J., van der Lelie D., Mergeay M.;
RT   "The complete genome sequence of Cupriavidus metallidurans strain CH34, a
RT   master survivalist in harsh and anthropogenic environments.";
RL   PLoS ONE 5:E10433-E10433(2010).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
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DR   EMBL; CP000352; ABF07322.1; -; Genomic_DNA.
DR   RefSeq; WP_011515310.1; NC_007973.1.
DR   AlphaFoldDB; Q1LRA4; -.
DR   SMR; Q1LRA4; -.
DR   STRING; 266264.Rmet_0436; -.
DR   EnsemblBacteria; ABF07322; ABF07322; Rmet_0436.
DR   KEGG; rme:Rmet_0436; -.
DR   eggNOG; COG1452; Bacteria.
DR   HOGENOM; CLU_009039_0_0_4; -.
DR   OMA; DYSHLDW; -.
DR   OrthoDB; 100018at2; -.
DR   Proteomes; UP000002429; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   Pfam; PF04453; LptD; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Reference proteome; Signal.
FT   SIGNAL          1..48
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           49..824
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_5000118484"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          67..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..116
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   824 AA;  91744 MW;  455B2DC58AA5187F CRC64;
     MTEQRRSPHH PATRPPAPPG TSRRVRLPAS ALRPLVLAMA GLTVSAHAQY GATSAIPNID
     LVEPVVTQTP EAPPPPAEGG DLVPRLTEPA TRTAPSGNTL NLSPSSTPSN PNAPAYVSGD
     RVTGYSEKGV EMEGHAELRR DGGVIKGDRL TYDQDTDEAH ATGNVRLSKS GTLAVGPEAR
     MRVQANEGYM LSPDYYFQQT GGSGSAERVD FLDPDRSTLK KATYTTCSPD NADWYFSARK
     LDLDSDRQVG TAYGGVLNFF GVPIAGAPAF SFPLNGERRS GVLPPLFGYG SNSGADLTVP
     YYFNLAPNRD LTIYPRILTS RGVQLGEDFR YVGDGYSGRI RGEFLPDDKK AGRNRWAYSI
     QHYQSIIPGM TAYVNVSKVS DDKYPDDLTR SVSQSTLRQY TQEGGVIYAW QDWVFMARVQ
     KFQTLLPSEP SYEREPQLNA KYNRYDFHGF DISLETDYTR FRIPLTSTGF QQPEGNRAFI
     QPTISYPIIH PGWYVTPKFI FNAAQYNMDA GTNTTGASNT LNRAIPTVSL DSGMTFERDA
     PGVSKLFGVK YTQTLEPRLF YVYTPFYDQS QFPLFDTVQS DFGYGQIFTE NPFTGNDRIA
     DNNKLTLGLT TRLIESETGV ERFRGTIAQR VDFTGQRVQL NGTLPDAKPS YSDLLAATTI
     QLFRGYYLDA GIQWNPDQDK VNYSNVALAY RPESRKLINF GYRYRRPTSV TDNTAIDQIE
     MSGQWPITQR TYGIGRVAFD KSANQLVDAL AGFEYAADCW VGRFVYQRFR NTSNGYTGRV
     FFQVEFRGLS KIGSNPLDML RLNVPGYEPV TARPVPTTPY DHYE