ID   LPTD_CUPNH              Reviewed;         813 AA.
AC   Q0KEB0;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=H16_A0511;
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
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DR   EMBL; AM260479; CAJ91661.1; -; Genomic_DNA.
DR   RefSeq; WP_011614549.1; NZ_CP039287.1.
DR   AlphaFoldDB; Q0KEB0; -.
DR   SMR; Q0KEB0; -.
DR   STRING; 381666.H16_A0511; -.
DR   EnsemblBacteria; CAJ91661; CAJ91661; H16_A0511.
DR   GeneID; 57642608; -.
DR   KEGG; reh:H16_A0511; -.
DR   PATRIC; fig|381666.6.peg.877; -.
DR   eggNOG; COG1452; Bacteria.
DR   HOGENOM; CLU_009039_0_0_4; -.
DR   OMA; DYSHLDW; -.
DR   OrthoDB; 100018at2; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF04453; LptD; 1.
DR   Pfam; PF03968; LptD_N; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Reference proteome; Signal.
FT   SIGNAL          1..52
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           53..813
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000281630"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   813 AA;  90866 MW;  785A4F7806FF3BC4 CRC64;
     MTEQRRSPNN RALPSPAPTS VPARARRAGG LHAGALRPLV LAMASLSAGA HAQMSGSAIP
     DLDQVEPVFE AAPKAPPLPV ESGELVPRLA EPGKQSDAGS DAPTFIEADR MTGYSERGVE
     LEGHAELRRD GGAIKGDKLT YDQDTDEAFA QGNVRMSRSG TLAVGPEARM KVEANEGYML
     SPDYYFQQTG GSGKAERIDF LDKDRSTARH ASYTTCSPDN ADWYFSANRI DLDNDRQVGV
     AYGGVLNFFG VPIAAAPAFS FPLNDDRRSG FLPPLMGYGS RSGFDLTTPY YVNIAPNRDL
     TIYPRLMTER GLQLGGEYRY LGQGYNGRLR AEFLPDDKKT NSNRWAYSIQ HNQNLAKGLN
     AYLNVNRVSD DQYPDDFNRS VSQSTLRQYT QEGGVTYNWQ DFTFLARVQK FQTLRPSEPS
     YERVPQLNGK YIRYDLGGFD VQVEADYTRF RIPLTSTGFQ QPQGERMFIQ PSISYPIVRA
     GWYVTPKVTF NATQYQMEAA SNTPTVQNNF SRVLPTMSLD SGMTFEREAP TVSRLFGVNY
     VQTLEPRLFY VYTPFRDQSQ FPLFDTVQSD FGYGQIFSEN PFTGYDRVAD NNKLTGGLTT
     RLIEADTGIE RFRGTIAQRY DFTGQRVQIN GTLADPKAGF SDLLAATTIQ MFRGYYLDAG
     VQYNPDSDRI NYGNVAVSYR PESRKVINAG YRYRRPTSVT DNTAIDQFEV SSQWPITRRA
     YGIARFAFDL AASQMVDALA GVEYAADCWV GRVVYQRFRN TTQGYTGRVF LQVEFRGLSK
     IGSNPLNILR LNVPGYEPVS AKPVPTTQFD HYE