ID   LPTD_FRATH              Reviewed;         868 AA.
AC   Q2A216;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=FTL_1597;
OS   Francisella tularensis subsp. holarctica (strain LVS).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=376619;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVS;
RA   Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S.,
RA   Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R.,
RA   Garcia E.;
RT   "Complete genome sequence of Francisella tularensis LVS (Live Vaccine
RT   Strain).";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
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DR   EMBL; AM233362; CAJ80036.1; -; Genomic_DNA.
DR   RefSeq; WP_003016981.1; NZ_CP009694.1.
DR   AlphaFoldDB; Q2A216; -.
DR   SMR; Q2A216; -.
DR   PRIDE; Q2A216; -.
DR   KEGG; ftl:FTL_1597; -.
DR   OMA; DYSHLDW; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF04453; LptD; 1.
DR   Pfam; PF03968; LptD_N; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           25..868
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000281604"
SQ   SEQUENCE   868 AA;  98611 MW;  C5C7C1E7B8C500F5 CRC64;
     MLKGIHKYLL MCFGTVLFTV QANAARIMSN NPIKEDWQCK VVDGEWSCKR AKKPKSVFDK
     KLTKTEKEKA LADDLAWVKK PSYFVGGYYS NDNQFTKALC ESKKTDLSYE KSEFDNYGTL
     IASGNVQVLQ CDQELYGNNA IINLNSNNSA IRSLVMAGDV IVKQPSTGIV IRTTELDADM
     NNGTYSTGEA YFRLAREMPK TRIYDKEHFS GYLRGYAKTF KKESSGDIVL SDGYITSGDP
     YDNAWKITGN NIDIDTNTHM AYVKNGYFEI QDIPVMYIPY FSHPIDDRRR SGFLYPGFLQ
     NANSGIGISV PYYFNLAPNY DLMLQSVIWS QRGIIENGTF RYMTKYFQGQ FEGSLVPYDF
     KEGKMRSSFT LSTTGQYENI NTNFKYEYVS DQNYYNDFSA GNVNLVTKTL LDREFDLTYT
     NDYVDSGLTV LDYGVVNPLL TVDNTPYAKL PEVKLNLTSD GYTPDYLTLS AQTLNTFFYK
     TAGPANTNPG APQGTNVNAF RAYESPKIAF NFNKTWGYLK PSLELPIRYY KLNNKPTDII
     KFKNSNVTSV LPIFNIDAGA YFDKDYTNEN GTYTSTLHPR LFYTYIPYQD QTNIPLFDTS
     LQNEQYMQMF QVNRFTGYDR INNANQLTYA IEASTTNQDN GTTLASAKIG QMAYFADRKV
     NLCQGNSACP NPGLMDPFST DTFSPIMSSF EFQVMKNIYL SAQVNYRVKQ QNVDYQVYQL
     SYKDENENIF NVSYNNIANN WNSLTQQQIA EGAKPQPQET ITLSTVLNIT DHWGIAALWN
     YNFQQKQIAN IFAGLQYNAK SWAVRALWQK TAYTNQDPNN PTLLGPLVNT YMFEFELKGL
     GGIGNTSDIS SRLQQINGYQ VGEWGNGI