ID   LPTD_FRATN              Reviewed;         868 AA.
AC   A0Q5D8;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=FTN_0558;
OS   Francisella tularensis subsp. novicida (strain U112).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=401614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=U112;
RX   PubMed=17550600; DOI=10.1186/gb-2007-8-6-r102;
RA   Rohmer L., Fong C., Abmayr S., Wasnick M., Larson Freeman T.J., Radey M.,
RA   Guina T., Svensson K., Hayden H.S., Jacobs M., Gallagher L.A., Manoil C.,
RA   Ernst R.K., Drees B., Buckley D., Haugen E., Bovee D., Zhou Y., Chang J.,
RA   Levy R., Lim R., Gillett W., Guenthener D., Kang A., Shaffer S.A.,
RA   Taylor G., Chen J., Gallis B., D'Argenio D.A., Forsman M., Olson M.V.,
RA   Goodlett D.R., Kaul R., Miller S.I., Brittnacher M.J.;
RT   "Comparison of Francisella tularensis genomes reveals evolutionary events
RT   associated with the emergence of human pathogenic strains.";
RL   Genome Biol. 8:R102.1-R102.16(2007).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
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DR   EMBL; CP000439; ABK89453.1; -; Genomic_DNA.
DR   RefSeq; WP_011733617.1; NZ_CP009633.1.
DR   AlphaFoldDB; A0Q5D8; -.
DR   SMR; A0Q5D8; -.
DR   EnsemblBacteria; ABK89453; ABK89453; FTN_0558.
DR   KEGG; ftn:FTN_0558; -.
DR   OMA; DYSHLDW; -.
DR   OrthoDB; 100018at2; -.
DR   BioCyc; FTUL401614:G1G75-580-MON; -.
DR   Proteomes; UP000000762; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF04453; LptD; 1.
DR   Pfam; PF03968; LptD_N; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           25..868
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000281606"
SQ   SEQUENCE   868 AA;  98376 MW;  FCE2C935D62D6342 CRC64;
     MLKGIHKYLL MCFGTVLFTV QANAARIMSN NPIKEDWQCK VVDGEWSCKR AKKPKSVFDK
     KLTKTEKEKA LADDLAWVKK PSYFVGGYYS NDSQFTKALC ESKKTDLSYE KSEFDNDGTL
     IASGNVQVLQ CDQELYGNNA IINLNSNNSA IRSLVMAGDV IVKQPSTGIV IRTTELDADM
     NDGTYSTGEA YFRLAREMPK TRIYDKEHFS GYLRGYAKTF KKESSGDIVL SDGYITSGDP
     YDNAWKITGN NIDIDTNTHM AYVKNGYFEI QDIPVMYIPY FSHPIDDRRR SGFLYPGFVQ
     NANSGIGISV PYYFNLAPNY DLMLQSVIWS QRGIMENGTF RYMTKYFQGQ FEGSLVPYDF
     KEGKMRGSFT LSTTGQYENI NTNFKYEYVS DQNYYNDFSA GNVNLVTKTL LDREFDLTYT
     NDYVDSGLTV LDYGVVNPLL TVDNTPYAKL PEVKLNLTSD GYTPDYLTLS AQTLNTFFYK
     TAGPANTNPG APQGTNVNAF RAYESPKIAF NFNKTWGYLN PSLEVPIRYY QLKNSPTDTI
     QFANSSVTSV LPIFNIDAGA YFDKDYTNEN GTYTSTLHPR LFYTYIPYQD QTNIPLFDTS
     LQNEQYMQMF QVNRFTGYDR INNANQLTYA LEASTTNQED GTTLASAKIG QMAYFADRKV
     NLCQGNSACP NPGLMDPFST DTFSPIMTSF EFQVMKNIYL SAQVNYRVKQ QNVDYQVYQL
     SYKDENENIF NVSYNNIANN WSSLTQQQIA EGAKPQPQET ITLSTILNIT DHWGIAALWN
     YNFQQKQIAN IFAGLQYNAK SWAVRALWQK TAYTNQDPNN PTLLGPLVNT YMFEFELKGL
     GGIGNTSDIS SRLQQINGYQ VGEWGDGI