ID   LPTD_HAEI8              Reviewed;         782 AA.
AC   Q4QMG4;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=NTHI0889;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=86-028NP;
RX   PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT   influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000057; AAX87783.1; -; Genomic_DNA.
DR   RefSeq; WP_005689018.1; NC_007146.2.
DR   AlphaFoldDB; Q4QMG4; -.
DR   SMR; Q4QMG4; -.
DR   EnsemblBacteria; AAX87783; AAX87783; NTHI0889.
DR   KEGG; hit:NTHI0889; -.
DR   HOGENOM; CLU_009039_2_0_6; -.
DR   OMA; DYSHLDW; -.
DR   OrthoDB; 100018at2; -.
DR   Proteomes; UP000002525; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF04453; LptD; 1.
DR   Pfam; PF03968; LptD_N; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           24..782
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000281609"
SQ   SEQUENCE   782 AA;  90215 MW;  393D02C10C720A2A CRC64;
     MNKKHTLISL AILTALYSQQ SLADLHEQCL MGVPKFSGEV VTGDVNSLPV YIEADNAEIN
     QPNDATYQGN VDLKQGNRHL LAQSVQVKQS GNQSTPLRMA YVRNGFDYKD NQINMLGKDA
     EFNLDSHDGN LTNSEYEFVG RQGRGKADNI TLHNNYRVMK NATFTSCLHG DNAWAVDASE
     IRQYVKEEYA EMWHARFKIH GVPVFYTPYL QLPIGDRRRS GLLIPSAGTS NRDGLWYAQP
     IYWNIAPNYD LTFTPKYMSR RGWQANGEFR YLTSIGEGKV AGEYLGKDRY SEYASDNRKR
     HLFYWNHNSS FLQNWRLNIN YTRVSDKRYF NDFDSIYGRS TDGYANQYAR IAYYQPNYNF
     SLSAHQFQIF DDIVNIGPYR AVPQLDFNYH KYDLANGWLN FKLHSQAVRF DNDSKLMPTA
     WRFHAEPSLN SLMSNKYGSL NIETKLYATR YEQKKGSGKN AEDVQKTVNR VIPQFKVDLQ
     SVLSRDITFL KEYTQTFEPH VQYLYRPYRN QSNIGSTLNN DYLGFGYDSA LVQQDYYSLF
     RDRRYSGLDR ISSANQVTLG GTTRFYDIAG EERFNLSAGQ IYYLSNSRID ENPANKTPTS
     SSAWALESNW KISNKWYWRG SYQFDTHTNS TSLANTSLEY NPEKNNLIQL NYRYVNQEYI
     DQNLGKSANA YQQDIQQVGL VVGWEIANNW AVVGRYYQDL ALQKPVEQYL GVQYNSCCWA
     ASVGVKRNVT NHQNQTRNEI VYDNSIGITL ELRGLGSNDH QSGIQEMLEK GKLPYIRAFS
     LD