ID   LPTD_HAEIN              Reviewed;         782 AA.
AC   P44846;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=HI_0730;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA   Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L42023; AAC22389.1; -; Genomic_DNA.
DR   PIR; G64157; G64157.
DR   RefSeq; NP_438889.1; NC_000907.1.
DR   RefSeq; WP_010869043.1; NC_000907.1.
DR   AlphaFoldDB; P44846; -.
DR   SMR; P44846; -.
DR   STRING; 71421.HI_0730; -.
DR   EnsemblBacteria; AAC22389; AAC22389; HI_0730.
DR   KEGG; hin:HI_0730; -.
DR   PATRIC; fig|71421.8.peg.764; -.
DR   eggNOG; COG1452; Bacteria.
DR   HOGENOM; CLU_009039_2_0_6; -.
DR   OMA; DYSHLDW; -.
DR   PhylomeDB; P44846; -.
DR   BioCyc; HINF71421:G1GJ1-770-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IBA:GO_Central.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF04453; LptD; 1.
DR   Pfam; PF03968; LptD_N; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Membrane; Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           24..782
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000020281"
SQ   SEQUENCE   782 AA;  90084 MW;  E73C8A5786B02D1B CRC64;
     MNKKHTLISL AILTALYSQQ SLADLHEQCL MGVPKFSGEV VTGDVNALPV YIEADNAEIN
     QPNDATYQGN VDLKQGNRHL LAQSVQVKQS GNQSTPLRMA YVRNGFDYKD NQINMLGKDA
     EFNLDSHDGN LTNSEYEFVG RQGRGKADNI TLHNNYRVMK NATFTSCLHG DNAWAVDASE
     IRQYVKEEYA EMWHARFKIH GVPVFYTPYL QLPIGDRRRS GLLIPSAGTS SQDGLWYAQP
     IYWNIAPNYD LTFTPKYMSR RGWQANGEFR YLTSIGEGKV AGEYLGKVRY SEYASDNRKR
     HLFYWNHNSS FLQNWRLNIN YTRVSDKRYF NDFDSIYGRS TDGYANQYAR IAYYQPNYNF
     SLSAHQFQIF DDIVNIGPYR AVPQLDFNYH KYDLANGWLN FKLHSQAVRF DNDSKLMPTA
     WRFHAEPSLN SLMSNKYGSL NIETKLYATR YEQKKGSGKN AEDVQKTVNR VIPQFKVDLQ
     SVLARDITFL KEYTQTFEPH VQYLYRPYRN QSNIGSTLNN DYLGFGYDSA LVQQDYYSLF
     RDRRYSGLDR ISSANQVTLG GTTRFYDIAG EERFNLSAGQ IYYLSNSRID ENPANKTPTS
     SSAWALESNW KISNKWYWRG SYQFDTHTNS TSLANTSLEY NPEKNNLIQL NYRYANQEYI
     DQNLGKSANA YQQDIQQVGL VVGWEIANNW AVVGRYYQDL ALQKPVEQYL GVQYNSCCWA
     ASVGVKRNVT NHQNQTRNEI VYDNSIGITL ELRGLGSNDH QSGIQEMLEK GKLPYIRAFS
     LD