ID   LPTD_LEGPH              Reviewed;         839 AA.
AC   Q5ZYR4;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=lpg0297;
OS   Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS   33152 / DSM 7513).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=272624;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513;
RX   PubMed=15448271; DOI=10.1126/science.1099776;
RA   Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA   Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA   Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA   Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA   Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA   Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA   Russo J.J.;
RT   "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL   Science 305:1966-1968(2004).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAU26404.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE017354; AAU26404.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_016356722.1; NC_002942.5.
DR   RefSeq; YP_094351.1; NC_002942.5.
DR   AlphaFoldDB; Q5ZYR4; -.
DR   SMR; Q5ZYR4; -.
DR   STRING; 272624.lpg0297; -.
DR   PaxDb; Q5ZYR4; -.
DR   PRIDE; Q5ZYR4; -.
DR   EnsemblBacteria; AAU26404; AAU26404; lpg0297.
DR   GeneID; 66489500; -.
DR   KEGG; lpn:lpg0297; -.
DR   PATRIC; fig|272624.6.peg.317; -.
DR   eggNOG; COG1452; Bacteria.
DR   HOGENOM; CLU_009039_0_0_6; -.
DR   Proteomes; UP000000609; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF04453; LptD; 1.
DR   Pfam; PF03968; LptD_N; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           22..839
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000281615"
SQ   SEQUENCE   839 AA;  95958 MW;  28CC215A9FAF860D CRC64;
     MAIGITACVL SLINYQGLAY SAALINEPIQ ACVIAREVDL TDDIRTKFAQ CLGWQADQSS
     PVCLGFYKPI AVTPLASPDE VRILADTASF YRTQRSTLSG HVEMQQGQRV VNAQTAYVYR
     DPKTNEVTKI EFLNHVRYLE PDRMMIARKA VVYPQDKSGE VEDVLYRFNT NRSNALLPAW
     GRASLIKRFA NQDYFLKEAT YTTCAPQDKA WAIEAESISI DNEKGKGIAR NAKLRIHEWP
     VLYTPYLSFP TNRDRKSGFL MPIVGYSNVG GADLGIPYYW NMAPNYDMTL VPHLYTKRGL
     MLGGQFRYLT SKSTGTFNGN FLPKDKAFGR FLQDNEVEFP QIRGLSTNRW EVNFVDSTQF
     LSDLQLNVNF QQVSDDYYLQ DFSTNLASVT QRQLLRQADL TYTTENWTFR GMGQSYQTLH
     PINEIPVSPV YERLPQLMAR GYYDDLPFNA QFNILGQYDQ FHWPNDSWNI ALNNMPQGPR
     FHLNPILSVP MMKPWGYVTP SVQFVENYYD ISRNYTWGTS RANYNLTIPR YSLDGGLYFE
     RDLHLKGTYY IQTLEPRLFY LRVPYYNQTL IPVYDSGFMI FNVDQLFRTN RFSGFDRIGD
     ANQLSYALTT RWLEDESGAE KANFSIGQIK YFSERRVQLC QSPTGFCTDN PDTFGNLSST
     FGTSPVASRA VYKFNPAWGI TGDYIWDPAT RATNNADLNL HYQPARNAII NGGYSYLVNG
     DVTQVRNNDT ENNALHQAIL SAAWPLSEKW SGIGAYSYNI SKNYSMMSFL GVQYDSCCWA
     MRILGGRIFR SLNEEFEPQY NNNIYLQILL KGLGSVASSD PSGILNTYIP GYYDPFRRR