ID   LPTD_METCA              Reviewed;        1030 AA.
AC   Q60B79;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=MCA0601;
OS   Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Methylococcales;
OC   Methylococcaceae; Methylococcus.
OX   NCBI_TaxID=243233;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33009 / NCIMB 11132 / Bath;
RX   PubMed=15383840; DOI=10.1371/journal.pbio.0020303;
RA   Ward N.L., Larsen O., Sakwa J., Bruseth L., Khouri H.M., Durkin A.S.,
RA   Dimitrov G., Jiang L., Scanlan D., Kang K.H., Lewis M.R., Nelson K.E.,
RA   Methe B.A., Wu M., Heidelberg J.F., Paulsen I.T., Fouts D.E., Ravel J.,
RA   Tettelin H., Ren Q., Read T.D., DeBoy R.T., Seshadri R., Salzberg S.L.,
RA   Jensen H.B., Birkeland N.K., Nelson W.C., Dodson R.J., Grindhaug S.H.,
RA   Holt I.E., Eidhammer I., Jonasen I., Vanaken S., Utterback T.R.,
RA   Feldblyum T.V., Fraser C.M., Lillehaug J.R., Eisen J.A.;
RT   "Genomic insights into methanotrophy: the complete genome sequence of
RT   Methylococcus capsulatus (Bath).";
RL   PLoS Biol. 2:1616-1628(2004).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAU93128.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE017282; AAU93128.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q60B79; -.
DR   SMR; Q60B79; -.
DR   STRING; 243233.MCA0601; -.
DR   EnsemblBacteria; AAU93128; AAU93128; MCA0601.
DR   KEGG; mca:MCA0601; -.
DR   eggNOG; COG1452; Bacteria.
DR   HOGENOM; CLU_009039_0_1_6; -.
DR   OMA; DYSHLDW; -.
DR   Proteomes; UP000006821; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR045659; LptD_2.
DR   InterPro; IPR007543; LptD_C.
DR   Pfam; PF04453; LptD; 1.
DR   Pfam; PF19838; LptD_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Reference proteome; Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           33..1030
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000281617"
FT   REGION          50..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1030 AA;  113203 MW;  D83C50629A695F26 CRC64;
     MEGPPTAAHA AAPLRTAVFL ALAASWQQPA VAVGNWNCAR STDDKQWECV AKRKDGGADT
     PAAPGPKAPP TALGEAALSQ SNRAAPSTAV SPPTGAAPVA GTGLRPPPPV PSAASPSPST
     MAGGPTEDEE DEESESAESE KAESTAAPQV AEGGSAGEPG GTPPARAPRP ETPLAASRFV
     PSGTVSVRKE AASPQSVAAH APGAPAGWTC KPQKESRSWD CNLVGPDPRG VARPVGAAGE
     PPEDWAQAAT ITEYDEQRFD RLLGMMPSNP WAGTCARGKR ESDAAKDFLL TSKDRLARKR
     APVEVHGNYG EMDDQEVATF TGDAEVTRYD QHVKGDFLSL NTEADTVNAR GSVFYREKGL
     AFASDTAFMR MEEDKGVLRN SQFIVETMPS RGVARVAHMD SDTHSHYETA TYTTCPPGNT
     DWMLHADEVT IDKETGRGDA SHAWMEFKGV PIFYTPYMDF PVDDRRQSGF LSPTFGQSKV
     NGFNLSVPYY FNLAPDYDLT LQAREMTSRG PLFGGDFRWL TEHQRIRLLG EVIPEDSQTK
     TTRGQAGFDA MGRWTDSLFT LVDLNYVSDS KYLNQLNNTL GLVSNTFVQS QAYADYTYSN
     GSVRLLGDYY QNIDPSIPTE QTPYYRLPSL RGNYNEQIGD SGFRFQANAE VVNFGHGGNN
     VKGQRLNIRP QISYPIQSPG SFLVPSVALQ NTTYMLQNQA AGTGSSLNRV APIFSVDSGL
     VFDRDFELGS ASLRQTLEPR VFYTYVPKIN QNDYPIFDSN YYDFTYYQLF RTNRFAGADR
     LADMNQVTLG LTSRFIDRDT GWERLTASLG KVFFITDPSV TLVNPYGANP LGVVLGPDQG
     QFVYGNYNKS YANVIGKVDT RLTEAFFLGG EAQLSPYTGR FERGSVGLQY NDRQNNLMNL
     SYRYREPLPN QPAIEQAATI GQNTTALNNT DISFRIPFLK DWHVIGRWQY SLLYNRTLES
     LVGLEHETCC WRFTVLGREY LNGVNQSNAP TTNTAIFVQM ELKGLTRLGD QVDRFLYRAI
     NGYRMPNEDF