ID   LPTD_METFK              Reviewed;         803 AA.
AC   Q1GZC1;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=Mfla_2149;
OS   Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylobacillus.
OX   NCBI_TaxID=265072;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KT / ATCC 51484 / DSM 6875;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Anderson I., Richardson P.;
RT   "Complete sequence of Methylobacillus flagellatus KT.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
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DR   EMBL; CP000284; ABE50416.1; -; Genomic_DNA.
DR   RefSeq; WP_011480370.1; NC_007947.1.
DR   AlphaFoldDB; Q1GZC1; -.
DR   SMR; Q1GZC1; -.
DR   STRING; 265072.Mfla_2149; -.
DR   EnsemblBacteria; ABE50416; ABE50416; Mfla_2149.
DR   KEGG; mfa:Mfla_2149; -.
DR   eggNOG; COG1452; Bacteria.
DR   HOGENOM; CLU_009039_0_0_4; -.
DR   OMA; DYSHLDW; -.
DR   OrthoDB; 100018at2; -.
DR   Proteomes; UP000002440; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF04453; LptD; 1.
DR   Pfam; PF03968; LptD_N; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Reference proteome; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           23..803
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000281616"
FT   REGION          134..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   803 AA;  90909 MW;  25D7B2EE8AF8CBF1 CRC64;
     MKIRPITFLV ALVCLGFGHA HAKDTQDTNV IDPSPENLPD PDAIIIEGDK VQVYLDRRLK
     SIGNASLSTG QQKVHGDTIE YDVQNEELHV IGNVRLETKG GRITGPELRM KPSESIGEMK
     KPAFELDSQF ANMPQFGTSG NRRQDNDNLV YSSNSTTPLT QQNIEDSGYA PGLSRKQGVS
     RGDASGVVFE GPDRKRLKDA RYTTCEVGSD DWYIRAKELE LDDYTRTGTA RNARVEFQGV
     PILWTPWINF SFLNQRKSGF LAPTWGTTSR SGFEFLVPFY WNIAPDMDAT IGTRFLSKRG
     VQFQGEFRYL NENYQGTANL EYLPSDSSTG ENRYYAKFAH LHNFHNGWTA AYNLEKVSDD
     RYFSEMSTRI VTTSRVNLPQ QAYVNYADEN WTFNALVQKF QTLDGLNYPL QRLPQLTLTG
     DNEWGPFDVK LFTQWANFDR NNDAISTQAT LGGGTLDTLV TGKRLVAYPS ISLPMARPYG
     YITPKLGLHY TQYQVDNGAF TLRDSNGNIT SQDEYQSQSR TLPIFSIDSG LYFDRDVRIV
     KNRYTQTLEP RMYYVYIPYR DQSLIPVYDS SISDLNMGSL FLENQFTGQD RINNANQLTL
     AFTSRMISKN TGEQRLAVTV GQRYYFADEK VYLPGVNPRS GDTSDIIGEI TARLLNNWNI
     DIFGQYNTDR SVYVRNNISA RYNPEPGKTL NIGYRYTEDR LDQINLSGQW PLGKGWYGLG
     RWNYSLRENQ PIEGIAGLEY DAGCWQARTV MQRVSTATAD ANYALYFQLE LGGLASIGQN
     PLKLLNRAIP GYTSSSLIPD SYQ