ID   LPTD_NEIMA              Reviewed;         802 AA.
AC   A1IU30;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=NMA2207;
OS   Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS   Z2491).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10761919; DOI=10.1038/35006655;
RA   Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA   Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA   Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA   Barrell B.G.;
RT   "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT   Z2491.";
RL   Nature 404:502-506(2000).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
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DR   EMBL; AL157959; CAM09300.1; -; Genomic_DNA.
DR   RefSeq; WP_002245292.1; NC_003116.1.
DR   AlphaFoldDB; A1IU30; -.
DR   SMR; A1IU30; -.
DR   EnsemblBacteria; CAM09300; CAM09300; NMA2207.
DR   KEGG; nma:NMA2207; -.
DR   HOGENOM; CLU_009039_0_0_4; -.
DR   OMA; DYSHLDW; -.
DR   Proteomes; UP000000626; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   Pfam; PF04453; LptD; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           30..802
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000281619"
SQ   SEQUENCE   802 AA;  88505 MW;  A0F4092151038EA6 CRC64;
     MARLFSLKPL VLALGFCFGT HCAAADAVAA EETDNPTAGG SVRSVSEPIQ PTSLSLGSTC
     LFCSNESGSP ERTEAAVQGS GEASIPEDYT RIVADRMEGQ SQVQVRAEGN VVVERNRTTL
     NADWADYDQS GDTVTAGDRF ALQQDGTLIR GETLTYNLEQ QTGEAHNVRM ETEHGGRRLQ
     SVSRTAEMLG EGHYKLTETQ FNTCSAGDAG WYVKAASVEA DREKGIGVAK HAAFVFGGVP
     IFYTPWADFP LDGNRKSGLL VPSLSAGSDG VSLSVPYYFN LAPNLDATFA PGVIGERGAV
     FDGQVRYLRP DYAGQSDLTW LPHDKKSGRN NRYQAKWQHR HDISDTLQAG VDFNQVSDSG
     YYRDFYGNKE IAGNVNLNRR VWLDYGGRAA GGSLNAGLSV LKYQTLANQS GYKDKPYALM
     PRLSADWRKN TGRAQIGVSA QFTRFSHDSR QDGSRLVVYP DIKWDFSNSW GYVRPKLGLH
     ATYYSLNRFG SQEARRVSRT LPIVNIDSGM TFERNTRMFG GGVLQTLEPR LFYNYIPAKS
     QNDLPNFDSS ESSFGYGQLF RENLYYGNDR INTANSLSAA VQSRILDGAT GEERFRAGIG
     QKFYFKNDAV MLDGSVGKKP RSRSDWVAFA SSGIGSRFIL DSSIHYNQND KRAENYAVGA
     SYRPAQGKVL NARYKYGRNE KIYLKSDGSY FYDKLSQLDL SAQWPLTRNL SAVVRYNYGF
     EAKKPIEVLA GAEYKSSCGC WGAGVYAQRY VTGENTYKNA VFFSLQLKDL SSVGRNPADR
     MDVAVPGYIP AHSLSAGRNK RP