LPTD_NEIMB
ID LPTD_NEIMB Reviewed; 802 AA.
AC Q9K187;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE Flags: Precursor;
GN Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN OrderedLocusNames=NMB0280;
OS Neisseria meningitidis serogroup B (strain MC58).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=122586;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC58;
RX PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA Moxon E.R., Rappuoli R., Venter J.C.;
RT "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT MC58.";
RL Science 287:1809-1815(2000).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17038831; DOI=10.4161/hv.1.2.1651;
RA Vipond C., Wheeler J.X., Jones C., Feavers I.M., Suker J.;
RT "Characterization of the protein content of a meningococcal outer membrane
RT vesicle vaccine by polyacrylamide gel electrophoresis and mass
RT spectrometry.";
RL Hum. Vaccin. 1:80-84(2005).
CC -!- FUNCTION: Together with LptE, is involved in the assembly of
CC lipopolysaccharide (LPS) at the surface of the outer membrane.
CC {ECO:0000255|HAMAP-Rule:MF_01411}.
CC -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC Rule:MF_01411}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC Rule:MF_01411}.
CC -!- MISCELLANEOUS: Present in outer membrane vesicle formulations which are
CC used as vaccines in human.
CC -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC Rule:MF_01411}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF40734.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE002098; AAF40734.1; ALT_INIT; Genomic_DNA.
DR PIR; E81217; E81217.
DR RefSeq; NP_273336.1; NC_003112.2.
DR RefSeq; WP_002243965.1; NC_003112.2.
DR AlphaFoldDB; Q9K187; -.
DR SMR; Q9K187; -.
DR STRING; 122586.NMB0280; -.
DR TCDB; 1.B.42.1.1; the outer membrane lipopolysaccharide export porin (lps-ep) family.
DR PaxDb; Q9K187; -.
DR EnsemblBacteria; AAF40734; AAF40734; NMB0280.
DR KEGG; nme:NMB0280; -.
DR PATRIC; fig|122586.8.peg.349; -.
DR HOGENOM; CLU_009039_0_0_4; -.
DR OMA; DYSHLDW; -.
DR Proteomes; UP000000425; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IBA:GO_Central.
DR GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR InterPro; IPR020889; LipoPS_assembly_LptD.
DR InterPro; IPR007543; LptD_C.
DR Pfam; PF04453; LptD; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Membrane; Reference proteome; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT CHAIN 26..802
FT /note="LPS-assembly protein LptD"
FT /id="PRO_0000281620"
SQ SEQUENCE 802 AA; 88693 MW; 3960E1F1C804B3AF CRC64;
MARLFSLKPL VLALGLCFGT HCAAADAVAA EETDNPTAGE SVRSVSEPIQ PTSLSLGSTC
LFCSNESGSP ERTEAAVQGS GEASIPEDYT RIVADRMEGQ SQVQVRAEGN VVVERNRTTL
NTDWADYDQS GDTVTAGDRF ALQQDGTLIR GETLTYNLEQ QTGEAHNVRM EIEQGGRRLQ
SVSRTAEMLG EGHYKLTETQ FNTCSAGDAG WYVKAASVEA DREKGIGVAK HAAFVFGGVP
IFYTPWADFP LDGNRKSGLL VPSLSAGSDG VSLSVPYYFN LAPNLDATFA PSVIGERGAV
FDGQVRYLRP DYAGQSDLTW LPHDKKSGRN NRYQAKWQHR HDISDTLQAG VDFNQVSDSG
YYRDFYGNKE IAGNVNLNRR VWLDYGGRAA GGSLNAGLSV LKYQTLANQS GYKDKPYALM
PRLSVEWRKN TGRAQIGVSA QFTRFSHDSR QDGSRLVVYP DIKWDFSNSW GYVRPKLGLH
ATYYSLNRFG SQEARRVSRT LPIVNIDSGA TFERNTRMFG GEVLQTLEPR LFYNYIPAKS
QNDLPNFDSS ESSFGYGQLF RENLYYGNDR INTANSLSAA VQSRILDGAT GEERFRAGIG
QKFYFKDDAV MLDGSVGKKP RNRSDWVAFA SGSIGSRFIL DSSIHYNQND KRAENYAVGA
SYRPAQGKVL NARYKYGRNE KIYLKSDGSY FYDKLSQLDL SAQWPLTRNL SAVVRYNYGF
EAKKPIEVLA GAEYKSSCGC WGAGVYAQRY VTGENTYKNA VFFSLQLKDL SSVGRNPADR
MDVAVPGYIT AHSLSAGRNK RP