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LPTD_NEIMB
ID   LPTD_NEIMB              Reviewed;         802 AA.
AC   Q9K187;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=NMB0280;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17038831; DOI=10.4161/hv.1.2.1651;
RA   Vipond C., Wheeler J.X., Jones C., Feavers I.M., Suker J.;
RT   "Characterization of the protein content of a meningococcal outer membrane
RT   vesicle vaccine by polyacrylamide gel electrophoresis and mass
RT   spectrometry.";
RL   Hum. Vaccin. 1:80-84(2005).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- MISCELLANEOUS: Present in outer membrane vesicle formulations which are
CC       used as vaccines in human.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF40734.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE002098; AAF40734.1; ALT_INIT; Genomic_DNA.
DR   PIR; E81217; E81217.
DR   RefSeq; NP_273336.1; NC_003112.2.
DR   RefSeq; WP_002243965.1; NC_003112.2.
DR   AlphaFoldDB; Q9K187; -.
DR   SMR; Q9K187; -.
DR   STRING; 122586.NMB0280; -.
DR   TCDB; 1.B.42.1.1; the outer membrane lipopolysaccharide export porin (lps-ep) family.
DR   PaxDb; Q9K187; -.
DR   EnsemblBacteria; AAF40734; AAF40734; NMB0280.
DR   KEGG; nme:NMB0280; -.
DR   PATRIC; fig|122586.8.peg.349; -.
DR   HOGENOM; CLU_009039_0_0_4; -.
DR   OMA; DYSHLDW; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IBA:GO_Central.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   Pfam; PF04453; LptD; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Membrane; Reference proteome; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           26..802
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000281620"
SQ   SEQUENCE   802 AA;  88693 MW;  3960E1F1C804B3AF CRC64;
     MARLFSLKPL VLALGLCFGT HCAAADAVAA EETDNPTAGE SVRSVSEPIQ PTSLSLGSTC
     LFCSNESGSP ERTEAAVQGS GEASIPEDYT RIVADRMEGQ SQVQVRAEGN VVVERNRTTL
     NTDWADYDQS GDTVTAGDRF ALQQDGTLIR GETLTYNLEQ QTGEAHNVRM EIEQGGRRLQ
     SVSRTAEMLG EGHYKLTETQ FNTCSAGDAG WYVKAASVEA DREKGIGVAK HAAFVFGGVP
     IFYTPWADFP LDGNRKSGLL VPSLSAGSDG VSLSVPYYFN LAPNLDATFA PSVIGERGAV
     FDGQVRYLRP DYAGQSDLTW LPHDKKSGRN NRYQAKWQHR HDISDTLQAG VDFNQVSDSG
     YYRDFYGNKE IAGNVNLNRR VWLDYGGRAA GGSLNAGLSV LKYQTLANQS GYKDKPYALM
     PRLSVEWRKN TGRAQIGVSA QFTRFSHDSR QDGSRLVVYP DIKWDFSNSW GYVRPKLGLH
     ATYYSLNRFG SQEARRVSRT LPIVNIDSGA TFERNTRMFG GEVLQTLEPR LFYNYIPAKS
     QNDLPNFDSS ESSFGYGQLF RENLYYGNDR INTANSLSAA VQSRILDGAT GEERFRAGIG
     QKFYFKDDAV MLDGSVGKKP RNRSDWVAFA SGSIGSRFIL DSSIHYNQND KRAENYAVGA
     SYRPAQGKVL NARYKYGRNE KIYLKSDGSY FYDKLSQLDL SAQWPLTRNL SAVVRYNYGF
     EAKKPIEVLA GAEYKSSCGC WGAGVYAQRY VTGENTYKNA VFFSLQLKDL SSVGRNPADR
     MDVAVPGYIT AHSLSAGRNK RP
 
 
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