ID   LPTD_PSEA8              Reviewed;         929 AA.
AC   B7V4I1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=PLES_05921;
OS   Pseudomonas aeruginosa (strain LESB58).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=557722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LESB58;
RX   PubMed=19047519; DOI=10.1101/gr.086082.108;
RA   Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I.,
RA   Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A.,
RA   Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D.,
RA   Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C.;
RT   "Newly introduced genomic prophage islands are critical determinants of in
RT   vivo competitiveness in the Liverpool epidemic strain of Pseudomonas
RT   aeruginosa.";
RL   Genome Res. 19:12-23(2009).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
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DR   EMBL; FM209186; CAW25319.1; -; Genomic_DNA.
DR   RefSeq; WP_012613530.1; NC_011770.1.
DR   AlphaFoldDB; B7V4I1; -.
DR   SMR; B7V4I1; -.
DR   PRIDE; B7V4I1; -.
DR   KEGG; pag:PLES_05921; -.
DR   HOGENOM; CLU_009039_1_0_6; -.
DR   OMA; DYSHLDW; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF04453; LptD; 1.
DR   Pfam; PF03968; LptD_N; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           34..929
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_1000145515"
FT   REGION          58..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   929 AA;  105226 MW;  2BF65AEE6AA02FDB CRC64;
     MAVKSLVFRR KFPLLVTGSL LALQPVAALT VQAADQFDCK VSATGGWDCS PLQNANANLP
     PRPAHTATSV STAAAGSSVS GSGGETVEAE PTQRLVTESG GRALKSRSAD YSHLDWIPRE
     KLTAAQLAEI GPYCGGSYIE PVRPGMDDGA PSDESPTYVS AKASRYEQEK QIATLAGDVV
     LRQGSMQVEG DEANLHQLEN RGELVGNVKL RDKGMLVVGD HAQVQLDNGE AQVDNAEYVI
     HKAHARGSAL YAKRSENAII MLKDGTYTRC EPSSNAWTLK GNNVKLNPAT GFGTATNATL
     RVKDFPVFYT PYIYFPIDDR RQSGFLPPSF SSTSDTGFTL VTPYYFNLAP NYDATLYPRY
     MAKRGMMLEG EFRYLTHSSE GTVNAAYLND KDDHRENFPD YSKDRWLYGL KNTTGLDSRW
     LAEVDYTRIS DPYYFQDLDT DLGVGSTTYV NQRGTLTYRG DTFTGRLNAQ AYQLATTTDV
     TPYERLPQIT FDGFLPYEPG GVKFNYSTEF VRFDRDLDDN IYLNDDGSEW GRRPDAYLQG
     LARSTGDRVH LEPGMSLPMT RSWGYLTPTL KYLYTKYDLD LDSQGKRTLT TYDETFDSSQ
     DRSLPLVKVD SGLYFDRDTT LAGTQFRQTL EPRAMYLYVP YKDQENIPVF DTSEPSFSYD
     SLWRENRFSG RDRIGDANQL SLGVTTRFIE SNGFERASLS AGQIYYFRDR RVQLPGLSEK
     DLALMRSKNP NLDLKDPDTD SWRSPYALMG QYRFNRDWRV SSDFNWNPNT SRTESGSAMF
     HYQPEDNPNK VVNAGYRYRE DSRRFNSSTG RFEYGRENDI IKQHDFSVIW PLVPQWSVLA
     RWQYDYNKNR TLEAFGGFEY DSCCWKLRLI NRYWLDVDDD AFLNQNEKAD RGIFLQIVLK
     GLGGIVGNKT EMFLDKGIQG YRQREDQAM