LPTD_PSEAE
ID LPTD_PSEAE Reviewed; 924 AA.
AC Q9I5U2;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE Flags: Precursor;
GN Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN OrderedLocusNames=PA0595;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Together with LptE, is involved in the assembly of
CC lipopolysaccharide (LPS) at the surface of the outer membrane.
CC {ECO:0000255|HAMAP-Rule:MF_01411}.
CC -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC Rule:MF_01411}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC Rule:MF_01411}.
CC -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC Rule:MF_01411}.
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DR EMBL; AE004091; AAG03984.1; -; Genomic_DNA.
DR PIR; C83572; C83572.
DR RefSeq; NP_249286.1; NC_002516.2.
DR RefSeq; WP_003113209.1; NZ_QZGE01000010.1.
DR PDB; 5IVA; X-ray; 2.99 A; A=300-924.
DR PDBsum; 5IVA; -.
DR AlphaFoldDB; Q9I5U2; -.
DR SMR; Q9I5U2; -.
DR DIP; DIP-62070N; -.
DR STRING; 287.DR97_3564; -.
DR ChEMBL; CHEMBL3879863; -.
DR PaxDb; Q9I5U2; -.
DR PRIDE; Q9I5U2; -.
DR DNASU; 880756; -.
DR EnsemblBacteria; AAG03984; AAG03984; PA0595.
DR GeneID; 880756; -.
DR KEGG; pae:PA0595; -.
DR PATRIC; fig|208964.12.peg.631; -.
DR PseudoCAP; PA0595; -.
DR HOGENOM; CLU_009039_1_0_6; -.
DR InParanoid; Q9I5U2; -.
DR OMA; DYSHLDW; -.
DR PhylomeDB; Q9I5U2; -.
DR BioCyc; PAER208964:G1FZ6-602-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IBA:GO_Central.
DR GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR GO; GO:0032885; P:regulation of polysaccharide biosynthetic process; IDA:PseudoCAP.
DR GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR InterPro; IPR020889; LipoPS_assembly_LptD.
DR InterPro; IPR007543; LptD_C.
DR InterPro; IPR005653; OstA-like_N.
DR Pfam; PF04453; LptD; 1.
DR Pfam; PF03968; LptD_N; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Membrane; Reference proteome; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT CHAIN 34..924
FT /note="LPS-assembly protein LptD"
FT /id="PRO_0000020285"
FT REGION 58..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 329..332
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 334..336
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 338..341
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 344..346
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 350..364
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 367..376
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 379..389
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 397..400
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 403..414
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 416..431
FT /evidence="ECO:0007829|PDB:5IVA"
FT HELIX 434..437
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 448..458
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 461..479
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 484..494
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 503..514
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 525..527
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 529..531
FT /evidence="ECO:0007829|PDB:5IVA"
FT HELIX 534..537
FT /evidence="ECO:0007829|PDB:5IVA"
FT HELIX 540..543
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 545..556
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 562..580
FT /evidence="ECO:0007829|PDB:5IVA"
FT HELIX 584..587
FT /evidence="ECO:0007829|PDB:5IVA"
FT HELIX 589..593
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 598..613
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 618..621
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 624..639
FT /evidence="ECO:0007829|PDB:5IVA"
FT HELIX 660..663
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 667..672
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 677..690
FT /evidence="ECO:0007829|PDB:5IVA"
FT TURN 691..693
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 694..708
FT /evidence="ECO:0007829|PDB:5IVA"
FT TURN 715..717
FT /evidence="ECO:0007829|PDB:5IVA"
FT HELIX 720..723
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 734..738
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 741..749
FT /evidence="ECO:0007829|PDB:5IVA"
FT TURN 750..752
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 753..762
FT /evidence="ECO:0007829|PDB:5IVA"
FT TURN 763..766
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 767..777
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 786..794
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 798..800
FT /evidence="ECO:0007829|PDB:5IVA"
FT TURN 802..804
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 805..810
FT /evidence="ECO:0007829|PDB:5IVA"
FT TURN 812..814
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 816..826
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 831..840
FT /evidence="ECO:0007829|PDB:5IVA"
FT TURN 841..844
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 845..856
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 861..874
FT /evidence="ECO:0007829|PDB:5IVA"
FT STRAND 880..893
FT /evidence="ECO:0007829|PDB:5IVA"
SQ SEQUENCE 924 AA; 104272 MW; 87F58C83E218335B CRC64;
MAVKSLVFRR KFPLLVTGSL LALQPVAALT VQAADQFDCK VSATGGWDCS PLQNANANLP
PRPAHTATSV STAAAGSSVS GSGGETVEAE PTQRLVTESG GRALKSRSAD YSHLDWIPRE
KLTAAQLAEI GPYCGGSYIE PVRPGMDDGA PSDESPTYVS AKASRYEQEK QIATLAGDVV
LRQGSMQVEG DEANLHQLEN RGELVGNVKL RDKGMLVVGD HAQVQLDNGE AQVDNAEYVI
HKAHARGSAL YAKRSENAII MLKDGTYTRC EPSSNAWTLK GNNVKLNPAT GFGTATNATL
RVKDFPVFYT PYIYFPIDDR RQSGFLPPSF SSTSDTGFTL VTPYYFNLAP NYDATLYPRY
MAKRGMMLEG EFRYLTHSSE GIVNAAYLND KDDHREGFPD YSKDRWLYGL KNTTGLDSRW
LAEVDYTRIS DPYYFQDLDT DLGVGSTTYV NQRGTLTYRG DTFTGRLNAQ AYQLATTTDV
TPYDRLPQIT FDGFLPYNPG GMQFTYGTEF VRFDRDLDEN IYFNDDGSIR GKRPDASLQG
LARATGDRMH LEPGMSLPMT RSWGYVTPTL KYLYTKYDLD LDSQGKTDLN KRDESFDSNQ
DRSLPLVKVD SGLYFDRDTT FAGTPFRQTL EPRAMYLYVP YKDQDSLPVF DTSEPSFSYD
SLWRENRFTG KDRIGDANQL SLGVTSRFIE ENGFERASIS AGQIYYFRDR RVQLPGLTEK
DLKRLNLDPS GLDNDSWRSP YAFAGQYRFN RDWRINSDFN WNPNTSRTES GSAIFHYQPE
VDPGKVVNVG YRYRADARRF DSSRGTFRYG NENDIIKQHD FSVIWPLVPQ WSVLARWQYD
YNKNRTLEAF GGFEYDSCCW KLRLINRYWL DVDDDAFLVQ SEKADRGIFL QIVLKGLGGI
VGNKTEMFLD KGIQGYRQRE DQAM
