ID   LPTD_PSEF5              Reviewed;         945 AA.
AC   Q4K4X8;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=PFL_5646;
OS   Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=220664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-477 / NRRL B-23932 / Pf-5;
RX   PubMed=15980861; DOI=10.1038/nbt1110;
RA   Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A.,
RA   Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J.,
RA   Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A., Rosovitz M.J.,
RA   Gwinn M.L., Zhou L., Schneider D.J., Cartinhour S.W., Nelson W.C.,
RA   Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A., Pierson L.S. III,
RA   Thomashow L.S., Loper J.E.;
RT   "Complete genome sequence of the plant commensal Pseudomonas fluorescens
RT   Pf-5.";
RL   Nat. Biotechnol. 23:873-878(2005).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
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DR   EMBL; CP000076; AAY94839.2; -; Genomic_DNA.
DR   RefSeq; WP_011063824.1; NC_004129.6.
DR   AlphaFoldDB; Q4K4X8; -.
DR   SMR; Q4K4X8; -.
DR   STRING; 220664.PFL_5646; -.
DR   EnsemblBacteria; AAY94839; AAY94839; PFL_5646.
DR   KEGG; pfl:PFL_5646; -.
DR   PATRIC; fig|220664.5.peg.5758; -.
DR   eggNOG; COG1452; Bacteria.
DR   HOGENOM; CLU_009039_1_0_6; -.
DR   OMA; DYSHLDW; -.
DR   OrthoDB; 100018at2; -.
DR   Proteomes; UP000008540; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF04453; LptD; 1.
DR   Pfam; PF03968; LptD_N; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Reference proteome; Signal.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           34..945
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000281626"
FT   REGION          56..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..78
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..98
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   945 AA;  106300 MW;  A06E38BA48844F04 CRC64;
     MALKSPAFRK KFPLLVTGSL LALQPLATSF VVAAEQYDCS VSASGGWACA PKTSAAQLPP
     RPVHDANSVS SSVATAADAT GEEASGDKSK LVTEAKGRGL KSRSADYSHL DWVPREKLTA
     AQLAETGPYC SGSYIEPIRP GMNDKTNKSD APTFIGAKAS RYQQEEQVAT LAGDVVMRQG
     SMQVEADEAS LYQAENRGEL SGNVRVRDNG ALLVGDHADI QLDTGEAKVD NAEYVLHKSR
     VRGNALYAKR AENAIIRLKD GTYTTCEPNS NAWQLKGNNI TLNPATGFGT ATNVTLRVKD
     IPVLYTPYIY FPIDDRRQSG FLPPSFSTGS DTGFMLVTPY YFNLAPNYDA TLYPRYMAKR
     GLLMEGEFRY LTKSSEGQFG AAYLNDDDTD RKKQTDYEKT RYMLNWQHKG GLDSRLMTEV
     DYTKISDPYY FQDLQTDQIG VKATDYVNQQ GVVTYRGDDY TARLNVQAYE LASVANITPY
     NKLPQITFNG ALPYHPQGLD FTYETELVRF DRDLLTGNYT DKDGGPIDPV TGAVGTRRLD
     TNVAGLARAN GDRLNLKPGV SLPLNWSYGY LTPSLKYMYT QYNLDLDGTG KEGIVAARNY
     ATATGTRYVG GDYSRNQNRG VPIASLDGGL YFDRNTQWFG KNYRQTLEPR AFYLYVPEED
     QKDIPVFDTG EPTFNYASLF RDNRFSGSDR VGDENKLSLG VTSRWIEDNG FQRQRISVGQ
     ALYFKDRTVQ LPGIDYRTRA DATSNVSPYA LEYEYRYNRD WRATADYNWD PDSHSARSGS
     AMFHYQPEDN PNKVVNAGYR YRNDQIRYDQ NSGTWKMGGD YGTPGQPGYV KDYYKIQQHD
     FSVIWPIVPQ WNAISRWQYD YNRNRTLEAF GGFEYDNCCW KLRLISRYWV KYDEFSQNAP
     ENEKGDRGIF LQIVLKGLGG VMGTKVESFL DKGIQGYRER EDQAF