ID   LPTD_SALPA              Reviewed;         784 AA.
AC   Q5PDE5;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=SPA0094;
OS   Salmonella paratyphi A (strain ATCC 9150 / SARB42).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=295319;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9150 / SARB42;
RX   PubMed=15531882; DOI=10.1038/ng1470;
RA   McClelland M., Sanderson K.E., Clifton S.W., Latreille P., Porwollik S.,
RA   Sabo A., Meyer R., Bieri T., Ozersky P., McLellan M., Harkins C.R.,
RA   Wang C., Nguyen C., Berghoff A., Elliott G., Kohlberg S., Strong C., Du F.,
RA   Carter J., Kremizki C., Layman D., Leonard S., Sun H., Fulton L., Nash W.,
RA   Miner T., Minx P., Delehaunty K., Fronick C., Magrini V., Nhan M.,
RA   Warren W., Florea L., Spieth J., Wilson R.K.;
RT   "Comparison of genome degradation in Paratyphi A and Typhi, human-
RT   restricted serovars of Salmonella enterica that cause typhoid.";
RL   Nat. Genet. 36:1268-1274(2004).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- PTM: Contains two intramolecular disulfide bonds. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
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DR   EMBL; CP000026; AAV76127.1; -; Genomic_DNA.
DR   RefSeq; WP_000746111.1; NC_006511.1.
DR   AlphaFoldDB; Q5PDE5; -.
DR   SMR; Q5PDE5; -.
DR   PRIDE; Q5PDE5; -.
DR   EnsemblBacteria; AAV76127; AAV76127; SPA0094.
DR   KEGG; spt:SPA0094; -.
DR   HOGENOM; CLU_009039_2_0_6; -.
DR   OMA; DYSHLDW; -.
DR   Proteomes; UP000008185; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF04453; LptD; 1.
DR   Pfam; PF03968; LptD_N; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Disulfide bond; Membrane; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           25..784
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000020287"
FT   DISULFID        31..724
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   DISULFID        173..725
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
SQ   SEQUENCE   784 AA;  89689 MW;  8FF7B081771BDA70 CRC64;
     MKKRIPTLLA TMIASALYSH QGLAADLASQ CMLGVPSYDR PLVKGDTNDL PVTINADNAK
     GNYPDDAVFT GNVDIMQGNS RLQADEVQLH QKQAEGQPEP VRTVDALGNV HYDDNQVILK
     GPKGWANLNT KDTNVWEGDY QMVGRQGRGK ADLMKQRGEN RYTILENGSF TSCLPGSDTW
     SVVGSEVIHD REEQVAEIWN ARFKVGPVPI FYSPYLQLPV GDKRRSGFLI PNAKYTTKNY
     FEFYLPYYWN IAPNMDATIT PHYMHRRGNI MWENEFRYLM QAGAGLMELD YLPSDKVYED
     EHPKEGDKHR WLFYWQHSGV MDQVWRFNVD YTKVSDSSYF NDFDSKYGSS TDGYATQKFS
     VGYAVQNFDA TVSTKQFQVF NDQNTSSYSA EPQLDVNYYH NDLGPFDTRI YGQAVHFVNT
     KDNMPEATRV HLEPTISLPL SNRWGSLNTE AKLMATHYQQ TNLDWYNANN SKKLEDSVNR
     VMPQFKVDGK LIFERDMAML APGYTQTLEP RVQYLYVPYR DQSGIYNYDS SLLQSDYNGL
     FRDRTYGGLD RIASANQVTT GVTTRIYDDA AVERFNVSVG QIYYFTESRT GDDNIKWEND
     DKTGSLVWAG DTYWRISERW GLRSGVQYDT RLDSVATSSS SLEYRRDQDR LVQLNYRYAS
     PEYIQATLPS YYSTAEQYKN GINQVGAVAS WPIADRWSIV GAYYFDTNSS KPADQMLGLQ
     YNSCCYAIRV GYERKLNGWD NDKQHAIYDN AIGFNIELRG LSSNYGLGTQ EMLRSNILPY
     QSSM