ID   LPTD_VIBCH              Reviewed;         783 AA.
AC   Q9KUR9;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 2.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=VC_0446;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF93619.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE003852; AAF93619.1; ALT_INIT; Genomic_DNA.
DR   PIR; E82323; E82323.
DR   RefSeq; NP_230100.1; NC_002505.1.
DR   RefSeq; WP_001277601.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KUR9; -.
DR   SMR; Q9KUR9; -.
DR   STRING; 243277.VC_0446; -.
DR   DNASU; 2615778; -.
DR   EnsemblBacteria; AAF93619; AAF93619; VC_0446.
DR   GeneID; 57739184; -.
DR   KEGG; vch:VC_0446; -.
DR   PATRIC; fig|243277.26.peg.420; -.
DR   eggNOG; COG1452; Bacteria.
DR   HOGENOM; CLU_009039_2_0_6; -.
DR   OMA; DYSHLDW; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0009279; C:cell outer membrane; IBA:GO_Central.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF04453; LptD; 1.
DR   Pfam; PF03968; LptD_N; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           25..783
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000020291"
SQ   SEQUENCE   783 AA;  88512 MW;  22EFE7E60707C0C9 CRC64;
     MSCFSRTFLA ASISAALFAP QIQAEASVDD NRAQLPNGEQ CLVNQPEPTN PGQQPINVEA
     DKLEAINGQK ATYSGNVVVV QGKKRIAADN VTLHQQENVV VAEGNVQFSD GEIKTHSTKA
     TNHLNTDEMT LENTRYQFLC EPGRGEAVYV SKTGKAVYEI EDGSITSCPD GDNAWRMRAS
     SIDVDQNEEI ATFYNPRLEV QNVPVFYLPY LTVPIGDTRK TGFLYPTASY GSRNGYSFEV
     PIYWNLAPQY DLETTFNYMQ KRGTQLNSVF RYLTDFGAGQ IKSEYLADDQ LHTELGDRWA
     FQYEHNGIFQ QAWKFEIDYS KVSDINYFSD LDSGVGNRED GQLIQEGRAT YRSDNWDSAL
     LVRDFQLLTK DTTSTNLPYR LMPQLSYNYY APETMKYLDL DLVSHVSRFE TDARGKPSAT
     RVHIEPGLKI PFSNTWGNWT TEARVLGTYY QQDLDKTTDA KLEESVTRVI PEIRSVAGIV
     LERDTVLLDD YTQTLEPKIQ YLYVPEKYQD NIGLYDSTLL QTDYYGLFRS RKYSGVDRIE
     SANQVSYGAS TRFFDSNYKE RLNIAFGQIF YLDSKLNPSN KNPDSTSDKT SYSAWAVEMD
     FNFADYLFYH GGIQYDIDSQ AVQLGNSTLE YRVASGYIQA NYRYVAKDYI RNTVGDSITN
     IDDITRDGIS QAGILAGYQL SRKWSASGQY YYDLTTDEAL EWLANLTYTS DCWYVGFTYS
     NQLKSWNGNF VTDPYATPIY ENNFSFNIGI IGFGTSIGAG SSMTGVDSAG NSLGYGRPFF
     LNN