LPTD_YERPE
ID LPTD_YERPE Reviewed; 780 AA.
AC Q8ZIK3; Q0WJH0;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE Flags: Precursor;
GN Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN OrderedLocusNames=YPO0495, y3680, YP_3684;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Together with LptE, is involved in the assembly of
CC lipopolysaccharide (LPS) at the surface of the outer membrane.
CC {ECO:0000255|HAMAP-Rule:MF_01411}.
CC -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC Rule:MF_01411}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC Rule:MF_01411}.
CC -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC Rule:MF_01411}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM87228.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL590842; CAL19175.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM87228.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS63832.1; -; Genomic_DNA.
DR PIR; AE0061; AE0061.
DR RefSeq; WP_002228111.1; NZ_WUCM01000024.1.
DR RefSeq; YP_002345568.1; NC_003143.1.
DR PDB; 5IXM; X-ray; 2.75 A; A/C/E/G=225-780.
DR PDBsum; 5IXM; -.
DR AlphaFoldDB; Q8ZIK3; -.
DR SMR; Q8ZIK3; -.
DR DIP; DIP-62066N; -.
DR IntAct; Q8ZIK3; 1.
DR STRING; 214092.YPO0495; -.
DR PaxDb; Q8ZIK3; -.
DR EnsemblBacteria; AAM87228; AAM87228; y3680.
DR EnsemblBacteria; AAS63832; AAS63832; YP_3684.
DR GeneID; 57974115; -.
DR KEGG; ype:YPO0495; -.
DR KEGG; ypk:y3680; -.
DR KEGG; ypm:YP_3684; -.
DR PATRIC; fig|214092.21.peg.745; -.
DR eggNOG; COG1452; Bacteria.
DR HOGENOM; CLU_009039_2_0_6; -.
DR OMA; DYSHLDW; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IBA:GO_Central.
DR GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR InterPro; IPR020889; LipoPS_assembly_LptD.
DR InterPro; IPR007543; LptD_C.
DR InterPro; IPR005653; OstA-like_N.
DR Pfam; PF04453; LptD; 1.
DR Pfam; PF03968; LptD_N; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Membrane; Reference proteome; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT CHAIN 25..780
FT /note="LPS-assembly protein LptD"
FT /id="PRO_0000020301"
FT STRAND 231..235
FT /evidence="ECO:0007829|PDB:5IXM"
FT TURN 236..238
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 239..243
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 254..263
FT /evidence="ECO:0007829|PDB:5IXM"
FT TURN 264..266
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 267..278
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 281..295
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 299..301
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 305..319
FT /evidence="ECO:0007829|PDB:5IXM"
FT TURN 320..322
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 323..334
FT /evidence="ECO:0007829|PDB:5IXM"
FT HELIX 337..340
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 351..362
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 364..379
FT /evidence="ECO:0007829|PDB:5IXM"
FT HELIX 380..385
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 388..402
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 405..417
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 425..440
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 445..460
FT /evidence="ECO:0007829|PDB:5IXM"
FT HELIX 463..466
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 476..490
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 493..496
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 498..500
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 504..516
FT /evidence="ECO:0007829|PDB:5IXM"
FT HELIX 537..540
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 544..549
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 554..566
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 572..585
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 589..591
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 601..613
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 615..627
FT /evidence="ECO:0007829|PDB:5IXM"
FT HELIX 628..630
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 632..647
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 649..657
FT /evidence="ECO:0007829|PDB:5IXM"
FT HELIX 659..665
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 678..688
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 690..702
FT /evidence="ECO:0007829|PDB:5IXM"
FT TURN 703..706
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 707..718
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 723..735
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 742..751
FT /evidence="ECO:0007829|PDB:5IXM"
FT HELIX 766..769
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 770..774
FT /evidence="ECO:0007829|PDB:5IXM"
SQ SEQUENCE 780 AA; 87909 MW; D4C3706260D2937A CRC64;
MKKRFPTLLA TLIWTALYSQ HTLADLAEQC MLGVPTYDQP LVTGDPNQLP VRINADKTEA
NYPDNALFTG NVIVQQGNST LTANQVELTQ VQKPGEVIPL RTVTATGDVN YDDPQIKLKG
PKGWSNLNTK DTDMDKGKYQ MVGRQGRGDA DLMKLRDQSR YTILKNGTFT SCLPGDNSWS
VVGSEVIHDR EEQVVEVWNA RFKIGKVPVF YSPYMQLPVG DKRRSGFLIP NAKFTSNNGF
EFLLPYYWNI APNFDATITP HYMERRGLQW QNEFRYLLAP GSGTMALDWL PNDRIYTGPD
GTDKNATRWL YYWGHSGVMD QVWRFNINYT RVSDPAYFTD LTSQYGSTTD GYATQIFTAG
YANENWNATL SSKQFQVFTA AGNSNAYRAQ PQLDMNYYKN DVGPFDMHVY GQAAKFTSVN
PTNPEASRFH IEPTVNLPLS NSWGSINTEA KLLATHYQQD IPASFADNAS NPKLKDSVNR
VLPQFKVDGK VVFDRSMDWA TGFTQTLEPR AQYLYVPYRN QDDIYIYDTT LMQSDYSGLF
RDRTYSGLDR IASANQVSTG LTSRIYDDAR VERFNVSVGQ IYYFSRSRTG NTEAIDNSNA
TGSLVWAGDT FWRINDQLGL KGGAQYDTRL GSLTLGNAIM EYRKDADRMI QLNYRYASPK
YIQAAVPKVY NPDYQQGISQ VGTTASWPIA DRWAIVGAYY YDTKAKQPAS QLVGLQYNTC
CWAVNLGYER KITGWNAQGQ TSKYDNKIGF NIELRGLSGG HSLGTAQMLN SGILPYQSAF
