ID   LPTD_YERPN              Reviewed;         780 AA.
AC   Q1CMS9; C4GNS1;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=YPN_0369; ORFNames=YP516_0377;
OS   Yersinia pestis bv. Antiqua (strain Nepal516).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=377628;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nepal516;
RX   PubMed=16740952; DOI=10.1128/jb.00124-06;
RA   Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M.,
RA   Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516:
RT   evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nepal516;
RA   Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L.,
RA   Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R.,
RA   Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.;
RT   "Yersinia pestis Nepal516A whole genome shotgun sequencing project.";
RL   Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABG16701.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000305; ABG16701.1; ALT_INIT; Genomic_DNA.
DR   EMBL; ACNQ01000006; EEO78153.1; -; Genomic_DNA.
DR   RefSeq; WP_002228111.1; NZ_ACNQ01000006.1.
DR   AlphaFoldDB; Q1CMS9; -.
DR   SMR; Q1CMS9; -.
DR   EnsemblBacteria; ABG16701; ABG16701; YPN_0369.
DR   GeneID; 57974115; -.
DR   KEGG; ypn:YPN_0369; -.
DR   HOGENOM; CLU_009039_2_0_6; -.
DR   Proteomes; UP000008936; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF04453; LptD; 1.
DR   Pfam; PF03968; LptD_N; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           25..780
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_5000115090"
SQ   SEQUENCE   780 AA;  87909 MW;  D4C3706260D2937A CRC64;
     MKKRFPTLLA TLIWTALYSQ HTLADLAEQC MLGVPTYDQP LVTGDPNQLP VRINADKTEA
     NYPDNALFTG NVIVQQGNST LTANQVELTQ VQKPGEVIPL RTVTATGDVN YDDPQIKLKG
     PKGWSNLNTK DTDMDKGKYQ MVGRQGRGDA DLMKLRDQSR YTILKNGTFT SCLPGDNSWS
     VVGSEVIHDR EEQVVEVWNA RFKIGKVPVF YSPYMQLPVG DKRRSGFLIP NAKFTSNNGF
     EFLLPYYWNI APNFDATITP HYMERRGLQW QNEFRYLLAP GSGTMALDWL PNDRIYTGPD
     GTDKNATRWL YYWGHSGVMD QVWRFNINYT RVSDPAYFTD LTSQYGSTTD GYATQIFTAG
     YANENWNATL SSKQFQVFTA AGNSNAYRAQ PQLDMNYYKN DVGPFDMHVY GQAAKFTSVN
     PTNPEASRFH IEPTVNLPLS NSWGSINTEA KLLATHYQQD IPASFADNAS NPKLKDSVNR
     VLPQFKVDGK VVFDRSMDWA TGFTQTLEPR AQYLYVPYRN QDDIYIYDTT LMQSDYSGLF
     RDRTYSGLDR IASANQVSTG LTSRIYDDAR VERFNVSVGQ IYYFSRSRTG NTEAIDNSNA
     TGSLVWAGDT FWRINDQLGL KGGAQYDTRL GSLTLGNAIM EYRKDADRMI QLNYRYASPK
     YIQAAVPKVY NPDYQQGISQ VGTTASWPIA DRWAIVGAYY YDTKAKQPAS QLVGLQYNTC
     CWAVNLGYER KITGWNAQGQ TSKYDNKIGF NIELRGLSGG HSLGTAQMLN SGILPYQSAF