LPTE_YERPE
ID LPTE_YERPE Reviewed; 207 AA.
AC Q7CJV2; Q74W07;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=LPS-assembly lipoprotein LptE {ECO:0000255|HAMAP-Rule:MF_01186};
DE Flags: Precursor;
GN Name=lptE {ECO:0000255|HAMAP-Rule:MF_01186}; Synonyms=rlpB;
GN OrderedLocusNames=YPO2609, y1183, YP_1104;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Together with LptD, is involved in the assembly of
CC lipopolysaccharide (LPS) at the surface of the outer membrane. Required
CC for the proper assembly of LptD. Binds LPS and may serve as the LPS
CC recognition site at the outer membrane. {ECO:0000255|HAMAP-
CC Rule:MF_01186}.
CC -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC complex. Interacts with LptD. {ECO:0000255|HAMAP-Rule:MF_01186}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC Rule:MF_01186}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_01186}.
CC -!- SIMILARITY: Belongs to the LptE lipoprotein family. {ECO:0000255|HAMAP-
CC Rule:MF_01186}.
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DR EMBL; AL590842; CAL21232.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84760.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS61350.1; -; Genomic_DNA.
DR PIR; AE0318; AE0318.
DR RefSeq; WP_002210332.1; NZ_WHLN01000015.1.
DR RefSeq; YP_002347565.1; NC_003143.1.
DR PDB; 5IXM; X-ray; 2.75 A; B/D/F/H=21-207.
DR PDBsum; 5IXM; -.
DR AlphaFoldDB; Q7CJV2; -.
DR SMR; Q7CJV2; -.
DR DIP; DIP-62067N; -.
DR IntAct; Q7CJV2; 1.
DR STRING; 214092.YPO2609; -.
DR PaxDb; Q7CJV2; -.
DR DNASU; 1146130; -.
DR EnsemblBacteria; AAM84760; AAM84760; y1183.
DR EnsemblBacteria; AAS61350; AAS61350; YP_1104.
DR GeneID; 66842474; -.
DR KEGG; ype:YPO2609; -.
DR KEGG; ypk:y1183; -.
DR KEGG; ypm:YP_1104; -.
DR PATRIC; fig|214092.21.peg.3039; -.
DR eggNOG; COG2980; Bacteria.
DR HOGENOM; CLU_103309_1_1_6; -.
DR OMA; TTVNRNY; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IBA:GO_Central.
DR GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IBA:GO_Central.
DR GO; GO:0015920; P:lipopolysaccharide transport; IBA:GO_Central.
DR HAMAP; MF_01186; LPS_assembly_LptE; 1.
DR InterPro; IPR007485; LPS_assembly_LptE.
DR PANTHER; PTHR38098; PTHR38098; 1.
DR Pfam; PF04390; LptE; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Lipoprotein; Membrane; Palmitate;
KW Reference proteome; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01186"
FT CHAIN 20..207
FT /note="LPS-assembly lipoprotein LptE"
FT /id="PRO_0000281191"
FT REGION 168..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 20
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01186"
FT LIPID 20
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01186"
FT STRAND 37..43
FT /evidence="ECO:0007829|PDB:5IXM"
FT HELIX 47..58
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 74..89
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 95..109
FT /evidence="ECO:0007829|PDB:5IXM"
FT STRAND 115..127
FT /evidence="ECO:0007829|PDB:5IXM"
FT HELIX 130..132
FT /evidence="ECO:0007829|PDB:5IXM"
FT HELIX 133..163
FT /evidence="ECO:0007829|PDB:5IXM"
SQ SEQUENCE 207 AA; 22570 MW; BED64D5961AA5E38 CRC64;
MRHRILTLLL GLAVLVTAGC GFNLRGTTQV PTELQKLLLE SSDPYGPLAR SIRQQLRLNN
VTIVDDAMRK DIPTLRIIGS SESQETVSIF RNGVAAENQL VLHVQAQVLI PGHDIYPLQV
NVFRTFFDNP LTALAKEAEA EVLRQEMREQ AAQQLVRQLL TVHAAEVKNT QKNGDKPVSD
ANAAQGSTPT AVNETTLGEP AVSTSAK
