LPT_ECOLI
ID LPT_ECOLI Reviewed; 21 AA.
AC P0AD86; P03059; Q2MCI0; Q6LEL1;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=thr operon leader peptide {ECO:0000255|HAMAP-Rule:MF_01907};
DE AltName: Full=thr operon attenuator {ECO:0000255|HAMAP-Rule:MF_01907};
GN Name=thrL {ECO:0000255|HAMAP-Rule:MF_01907};
GN OrderedLocusNames=b0001, JW4367;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=287010; DOI=10.1073/pnas.76.4.1706;
RA Gardner J.F.;
RT "Regulation of the threonine operon: tandem threonine and isoleucine codons
RT in the control region and translational control of transcription
RT termination.";
RL Proc. Natl. Acad. Sci. U.S.A. 76:1706-1710(1979).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6277952; DOI=10.1016/s0021-9258(18)34867-1;
RA Gardner J.F.;
RT "Initiation, pausing, and termination of transcription in the threonine
RT operon regulatory region of Escherichia coli.";
RL J. Biol. Chem. 257:3896-3904(1982).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2410621; DOI=10.1016/0022-2836(85)90169-x;
RA Lynn S.P., Bauer C.E., Chapman K.A., Gardner J.F.;
RT "Identification and characterization of mutants affecting transcription
RT termination at the threonine operon attenuator.";
RL J. Mol. Biol. 183:529-541(1985).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- FUNCTION: This protein is involved in control of the biosynthesis of
CC threonine.
CC -!- SIMILARITY: Belongs to the thr operon leader peptide family.
CC {ECO:0000255|HAMAP-Rule:MF_01907}.
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DR EMBL; J01706; AAA83913.1; -; Genomic_DNA.
DR EMBL; V00360; CAA23658.1; -; Genomic_DNA.
DR EMBL; X68872; CAA48733.1; -; Genomic_DNA.
DR EMBL; M28570; AAA24672.1; -; Genomic_DNA.
DR EMBL; U14003; AAA97300.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73112.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76026.1; -; Genomic_DNA.
DR PIR; A03595; LFECT.
DR RefSeq; NP_414542.1; NC_000913.3.
DR RefSeq; WP_001386572.1; NZ_STEB01000033.1.
DR AlphaFoldDB; P0AD86; -.
DR BioGRID; 4261932; 4.
DR STRING; 511145.b0001; -.
DR PaxDb; P0AD86; -.
DR EnsemblBacteria; AAC73112; AAC73112; b0001.
DR EnsemblBacteria; BAE76026; BAE76026; BAE76026.
DR GeneID; 67416081; -.
DR GeneID; 944742; -.
DR KEGG; ecj:JW4367; -.
DR KEGG; eco:b0001; -.
DR EchoBASE; EB1255; -.
DR HOGENOM; CLU_221491_0_1_6; -.
DR BioCyc; EcoCyc:EG11277-MON; -.
DR PRO; PR:P0AD86; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0031555; P:transcriptional attenuation; IMP:EcoCyc.
DR GO; GO:0031556; P:transcriptional attenuation by ribosome; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01907; Leader_Thr; 1.
DR InterPro; IPR011720; Thr_lead_pept.
DR Pfam; PF08254; Leader_Thr; 1.
DR TIGRFAMs; TIGR02077; thr_lead_pep; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Leader peptide; Reference proteome;
KW Threonine biosynthesis.
FT PEPTIDE 1..21
FT /note="thr operon leader peptide"
FT /id="PRO_0000044007"
SQ SEQUENCE 21 AA; 2138 MW; 6A9C9167F89EECE4 CRC64;
MKRISTTITT TITITTGNGA G
