LPW_ECOLI
ID LPW_ECOLI Reviewed; 14 AA.
AC P0AD92; P03053; Q2MBG1;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=trp operon leader peptide;
GN Name=trpL; Synonyms=trpEE; OrderedLocusNames=b1265, JW1257;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7038627; DOI=10.1093/nar/9.24.6647;
RA Yanofsky C., Platt T., Crawford I.P., Nichols B.P., Christie G.E.,
RA Horowitz H., van Cleemput M., Wu A.M.;
RT "The complete nucleotide sequence of the tryptophan operon of Escherichia
RT coli.";
RL Nucleic Acids Res. 9:6647-6668(1981).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=781271; DOI=10.1016/0022-2836(76)90317-x;
RA Squires C., Lee F., Bertrand K., Squires C.L., Bronson M.J., Yanofsky C.;
RT "Nucleotide sequence of the 5' end of tryptophan messenger RNA of
RT Escherichia coli.";
RL J. Mol. Biol. 103:351-381(1976).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=118451; DOI=10.1073/pnas.76.11.5524;
RA Oxender D.L., Zurawski G., Yanofsky C.;
RT "Attenuation in the Escherichia coli tryptophan operon: role of RNA
RT secondary structure involving the tryptophan codon region.";
RL Proc. Natl. Acad. Sci. U.S.A. 76:5524-5528(1979).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [6]
RP STRUCTURE BY NMR.
RX PubMed=7505428; DOI=10.1093/nar/21.23.5485;
RA Ramesh V.;
RT "NMR evidence for the RNA stem-loop structure involved in the transcription
RT attenuation of E. coli trp operon.";
RL Nucleic Acids Res. 21:5485-5488(1993).
CC -!- FUNCTION: This protein is involved in control of the biosynthesis of
CC tryptophan.
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DR EMBL; J01714; AAA57296.1; -; Genomic_DNA.
DR EMBL; U00096; AAC74347.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76395.1; -; Genomic_DNA.
DR PIR; A03589; LFECW.
DR RefSeq; NP_415781.1; NC_000913.3.
DR RefSeq; WP_001700591.1; NZ_STEB01000005.1.
DR PRIDE; P0AD92; -.
DR EnsemblBacteria; AAC74347; AAC74347; b1265.
DR EnsemblBacteria; BAE76395; BAE76395; BAE76395.
DR GeneID; 67417416; -.
DR GeneID; 945856; -.
DR KEGG; ecj:JW1257; -.
DR KEGG; eco:b1265; -.
DR EchoBASE; EB1252; -.
DR HOGENOM; CLU_222400_0_0_6; -.
DR BioCyc; EcoCyc:EG11274-MON; -.
DR PRO; PR:P0AD92; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0090357; P:regulation of tryptophan metabolic process; IDA:EcoCyc.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR013205; Leader_Trp_op.
DR Pfam; PF08255; Leader_Trp; 1.
PE 1: Evidence at protein level;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Leader peptide;
KW Reference proteome; Tryptophan biosynthesis.
FT PEPTIDE 1..14
FT /note="trp operon leader peptide"
FT /id="PRO_0000044023"
SQ SEQUENCE 14 AA; 1723 MW; 5B79306E3E804A37 CRC64;
MKAIFVLKGW WRTS