5HT3C_HUMAN
ID 5HT3C_HUMAN Reviewed; 447 AA.
AC Q8WXA8; A2RRR5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=5-hydroxytryptamine receptor 3C;
DE Short=5-HT3-C;
DE Short=5-HT3C;
DE AltName: Full=Serotonin receptor 3C;
DE Flags: Precursor;
GN Name=HTR3C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS LYS-163 AND
RP ALA-405.
RC TISSUE=Lung;
RX PubMed=12801637; DOI=10.1016/s0378-1119(03)00503-1;
RA Niesler B., Frank B., Kapeller J., Rappold G.A.;
RT "Cloning, physical mapping and expression analysis of the human 5-HT3
RT serotonin receptor-like genes HTR3C, HTR3D and HTR3E.";
RL Gene 310:101-111(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=17392525; DOI=10.1124/mol.106.032144;
RA Niesler B., Walstab J., Combrink S., Moeller D., Kapeller J., Rietdorf J.,
RA Boenisch H., Goethert M., Rappold G., Bruess M.;
RT "Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-
RT HT3D, and 5-HT3E.";
RL Mol. Pharmacol. 72:8-17(2007).
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] MET-128.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: This is one of the several different receptors for 5-
CC hydroxytryptamine (serotonin), a biogenic hormone that functions as a
CC neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-
CC gated ion channel, which when activated causes fast, depolarizing
CC responses. It is a cation-specific, but otherwise relatively
CC nonselective, ion channel.
CC -!- SUBUNIT: Forms a pentaheteromeric complex with HTR3A. Not functional as
CC a homomeric complex. {ECO:0000269|PubMed:17392525}.
CC -!- INTERACTION:
CC Q8WXA8; P46098: HTR3A; NbExp=5; IntAct=EBI-9008753, EBI-9008743;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17392525};
CC Multi-pass membrane protein {ECO:0000269|PubMed:17392525}.
CC Note=Presumably retained within the endoplasmic reticulum unless
CC complexed with HTR3A.
CC -!- TISSUE SPECIFICITY: Expressed in many tissues including adult brain,
CC colon, intestine, lung, muscle and stomach as well as fetal colon and
CC kidney. {ECO:0000269|PubMed:12801637}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; AF459285; AAL66182.1; -; mRNA.
DR EMBL; CH471052; EAW78305.1; -; Genomic_DNA.
DR EMBL; BC131799; AAI31800.1; -; mRNA.
DR CCDS; CCDS3250.1; -.
DR RefSeq; NP_570126.2; NM_130770.2.
DR AlphaFoldDB; Q8WXA8; -.
DR SMR; Q8WXA8; -.
DR BioGRID; 128062; 90.
DR ComplexPortal; CPX-276; 5-hydroxytryptamine-3A/C receptor complex.
DR IntAct; Q8WXA8; 42.
DR STRING; 9606.ENSP00000322617; -.
DR BindingDB; Q8WXA8; -.
DR ChEMBL; CHEMBL4296091; -.
DR DrugBank; DB01239; Chlorprothixene.
DR DrugBank; DB11273; Dihydroergocornine.
DR DrugBank; DB13345; Dihydroergocristine.
DR DrugBank; DB01049; Ergoloid mesylate.
DR DrugBank; DB00898; Ethanol.
DR DrugBank; DB12141; Gilteritinib.
DR DrugBank; DB00715; Paroxetine.
DR DrugBank; DB09304; Setiptiline.
DR DrugBank; DB13025; Tiapride.
DR DrugBank; DB00246; Ziprasidone.
DR DrugCentral; Q8WXA8; -.
DR iPTMnet; Q8WXA8; -.
DR PhosphoSitePlus; Q8WXA8; -.
DR BioMuta; HTR3C; -.
DR DMDM; 166198366; -.
DR MassIVE; Q8WXA8; -.
DR PaxDb; Q8WXA8; -.
DR PeptideAtlas; Q8WXA8; -.
DR PRIDE; Q8WXA8; -.
DR Antibodypedia; 33786; 100 antibodies from 21 providers.
DR DNASU; 170572; -.
DR Ensembl; ENST00000318351.2; ENSP00000322617.1; ENSG00000178084.2.
DR GeneID; 170572; -.
DR KEGG; hsa:170572; -.
DR MANE-Select; ENST00000318351.2; ENSP00000322617.1; NM_130770.3; NP_570126.2.
DR UCSC; uc003fmk.4; human.
DR CTD; 170572; -.
DR DisGeNET; 170572; -.
DR GeneCards; HTR3C; -.
DR HGNC; HGNC:24003; HTR3C.
DR HPA; ENSG00000178084; Tissue enriched (lung).
DR MIM; 610121; gene.
DR neXtProt; NX_Q8WXA8; -.
DR OpenTargets; ENSG00000178084; -.
DR PharmGKB; PA134925741; -.
DR VEuPathDB; HostDB:ENSG00000178084; -.
DR eggNOG; KOG3645; Eukaryota.
DR GeneTree; ENSGT00940000156739; -.
DR HOGENOM; CLU_018074_5_2_1; -.
DR InParanoid; Q8WXA8; -.
DR OMA; QWVQFSH; -.
DR OrthoDB; 123230at2759; -.
DR PhylomeDB; Q8WXA8; -.
DR TreeFam; TF315605; -.
DR PathwayCommons; Q8WXA8; -.
DR Reactome; R-HSA-112314; Neurotransmitter receptors and postsynaptic signal transmission.
DR SignaLink; Q8WXA8; -.
DR SIGNOR; Q8WXA8; -.
DR BioGRID-ORCS; 170572; 9 hits in 1061 CRISPR screens.
DR GeneWiki; HTR3C; -.
DR GenomeRNAi; 170572; -.
DR Pharos; Q8WXA8; Tchem.
DR PRO; PR:Q8WXA8; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8WXA8; protein.
DR Bgee; ENSG00000178084; Expressed in right lung and 11 other tissues.
DR Genevisible; Q8WXA8; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:1904602; C:serotonin-activated cation-selective channel complex; IPI:ComplexPortal.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0022850; F:serotonin-gated cation-selective channel activity; IDA:CACAO.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0098662; P:inorganic cation transmembrane transport; IDA:ComplexPortal.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007210; P:serotonin receptor signaling pathway; IDA:ComplexPortal.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 1.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..447
FT /note="5-hydroxytryptamine receptor 3C"
FT /id="PRO_0000312292"
FT TOPO_DOM 28..248
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..282
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..306
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..329
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 330..424
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 446..447
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 380..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 162..176
FT /evidence="ECO:0000250"
FT VARIANT 128
FT /note="V -> M (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs142791028)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_037552"
FT VARIANT 163
FT /note="N -> K (in dbSNP:rs6766410)"
FT /evidence="ECO:0000269|PubMed:12801637"
FT /id="VAR_037476"
FT VARIANT 405
FT /note="G -> A (in dbSNP:rs6807362)"
FT /evidence="ECO:0000269|PubMed:12801637"
FT /id="VAR_037477"
SQ SEQUENCE 447 AA; 50220 MW; E99260743598E596 CRC64;
MEGGWPARQS ALLCLTVSLL LQGRGDAFTI NCSGFDQHGV DPAVFQAVFD RKAFRPFTNY
SIPTRVNISF TLSAILGVDA QLQLLTSFLW MDLVWDNPFI NWNPKECVGI NKLTVLAENL
WLPDIFIVES MDVDQTPSGL TAYISSEGRI KYDKPMRVTS ICNLDIFYFP FDQQNCTFTF
SSFLYTVDSM LLGMDKEVWE ITDTSRKVIQ TQGEWELLGI NKATPKMSMG NNLYDQIMFY
VAIRRRPSLY IINLLVPSSF LVAIDALSFY LPAESENRAP FKITLLLGYN VFLLMMNDLL
PASGTPLISV YFALCLSLMV VSLLETVFIT YLLHVATTQP PPMPRWLHSL LLHCTSPGRC
CPTAPQKGNK GLGLTLTHLP GPKEPGELAG KKLGPRETEP DGGSGWTKTQ LMELWVQFSH
AMDTLLFRLY LLFMASSILT VIVLWNT
