LPXB_ALISL
ID LPXB_ALISL Reviewed; 383 AA.
AC B6EJW7;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Lipid-A-disaccharide synthase {ECO:0000255|HAMAP-Rule:MF_00392};
DE EC=2.4.1.182 {ECO:0000255|HAMAP-Rule:MF_00392};
GN Name=lpxB {ECO:0000255|HAMAP-Rule:MF_00392}; OrderedLocusNames=VSAL_I2414;
OS Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain
OS LFI1238)).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Aliivibrio.
OX NCBI_TaxID=316275;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LFI1238;
RX PubMed=19099551; DOI=10.1186/1471-2164-9-616;
RA Hjerde E., Lorentzen M.S., Holden M.T., Seeger K., Paulsen S., Bason N.,
RA Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S.,
RA Thurston S., Parkhill J., Willassen N.P., Thomson N.R.;
RT "The genome sequence of the fish pathogen Aliivibrio salmonicida strain
RT LFI1238 shows extensive evidence of gene decay.";
RL BMC Genomics 9:616-616(2008).
CC -!- FUNCTION: Condensation of UDP-2,3-diacylglucosamine and 2,3-
CC diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor
CC of lipid A, a phosphorylated glycolipid that anchors the
CC lipopolysaccharide to the outer membrane of the cell.
CC {ECO:0000255|HAMAP-Rule:MF_00392}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-
CC glucosamine = a lipid A disaccharide + H(+) + UDP;
CC Xref=Rhea:RHEA:67828, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:137748, ChEBI:CHEBI:176338, ChEBI:CHEBI:176343;
CC EC=2.4.1.182; Evidence={ECO:0000255|HAMAP-Rule:MF_00392};
CC -!- PATHWAY: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00392}.
CC -!- SIMILARITY: Belongs to the LpxB family. {ECO:0000255|HAMAP-
CC Rule:MF_00392}.
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DR EMBL; FM178379; CAQ80098.1; -; Genomic_DNA.
DR RefSeq; WP_012550902.1; NC_011312.1.
DR AlphaFoldDB; B6EJW7; -.
DR SMR; B6EJW7; -.
DR STRING; 316275.VSAL_I2414; -.
DR CAZy; GT19; Glycosyltransferase Family 19.
DR EnsemblBacteria; CAQ80098; CAQ80098; VSAL_I2414.
DR KEGG; vsa:VSAL_I2414; -.
DR eggNOG; COG0763; Bacteria.
DR HOGENOM; CLU_036577_3_0_6; -.
DR OMA; PTVWAWR; -.
DR OrthoDB; 1258510at2; -.
DR UniPathway; UPA00973; -.
DR Proteomes; UP000001730; Chromosome 1.
DR GO; GO:0008915; F:lipid-A-disaccharide synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00392; LpxB; 1.
DR InterPro; IPR003835; Glyco_trans_19.
DR PANTHER; PTHR30372; PTHR30372; 1.
DR Pfam; PF02684; LpxB; 1.
DR TIGRFAMs; TIGR00215; lpxB; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase; Lipid A biosynthesis; Lipid biosynthesis;
KW Lipid metabolism; Transferase.
FT CHAIN 1..383
FT /note="Lipid-A-disaccharide synthase"
FT /id="PRO_1000191458"
SQ SEQUENCE 383 AA; 42929 MW; 1DEC4146FE77622D CRC64;
MTKPLRIGIV AGELSGDTLG EGFIKSVKAQ YPNAEFVGIG GPKMIAQGCE SLFDMEELAV
MGLVEVLGRL PRLLKVKAEL VRYFSQNPPD VFIGIDAPDF NLRLEKTLKD SGIKTVHYVS
PSVWAWRPKR IFKIDAATDL VLAFLPFEKV FYDKYNVACE FIGHTLADAI PMQSDKIAAR
KLLGLELDRQ WLAVLPGSRG GEVALIAKPF IETCQRIHQK HPNMGFVVAA VNEKRREQFE
VIWKETAPEL KFIIIQDTAR NVMTAADSVL LASGTVALEC MLIKRPMVVG YQVNKLTGWI
AQKLSITEFV SLPNVLAGKE LVQEFIQEEC HPDFLYPAME KVLSQDNSEL IDRFTEMHQW
IKKDADKQAA NAVLRLINKE TAE