ID   LPXB_CHLMU              Reviewed;         607 AA.
AC   Q9PJY4;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Lipid-A-disaccharide synthase;
DE            EC=2.4.1.182;
GN   Name=lpxB; OrderedLocusNames=TC_0692;
OS   Chlamydia muridarum (strain MoPn / Nigg).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=243161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- FUNCTION: Condensation of UDP-2,3-diacylglucosamine and 2,3-
CC       diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor
CC       of lipid A, a phosphorylated glycolipid that anchors the
CC       lipopolysaccharide to the outer membrane of the cell. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-
CC         glucosamine = a lipid A disaccharide + H(+) + UDP;
CC         Xref=Rhea:RHEA:67828, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:137748, ChEBI:CHEBI:176338, ChEBI:CHEBI:176343;
CC         EC=2.4.1.182;
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the LpxB family.
CC       {ECO:0000305}.
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DR   EMBL; AE002160; AAF39508.1; -; Genomic_DNA.
DR   PIR; E81676; E81676.
DR   RefSeq; WP_010231237.1; NZ_CP027217.1.
DR   AlphaFoldDB; Q9PJY4; -.
DR   SMR; Q9PJY4; -.
DR   STRING; 243161.TC_0692; -.
DR   CAZy; GT19; Glycosyltransferase Family 19.
DR   EnsemblBacteria; AAF39508; AAF39508; TC_0692.
DR   GeneID; 1246053; -.
DR   KEGG; cmu:TC_0692; -.
DR   eggNOG; COG0763; Bacteria.
DR   eggNOG; COG3952; Bacteria.
DR   HOGENOM; CLU_430672_0_0_0; -.
DR   OMA; KIIHYVC; -.
DR   OrthoDB; 149100at2; -.
DR   UniPathway; UPA00973; -.
DR   Proteomes; UP000000800; Chromosome.
DR   GO; GO:0008915; F:lipid-A-disaccharide synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00392; LpxB; 1.
DR   InterPro; IPR003835; Glyco_trans_19.
DR   InterPro; IPR011499; Lipid_A_biosynth_N.
DR   PANTHER; PTHR30372; PTHR30372; 1.
DR   Pfam; PF07578; LAB_N; 2.
DR   Pfam; PF02684; LpxB; 1.
DR   SMART; SM01259; LAB_N; 2.
DR   TIGRFAMs; TIGR00215; lpxB; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Lipid A biosynthesis; Lipid biosynthesis;
KW   Lipid metabolism; Transferase.
FT   CHAIN           1..607
FT                   /note="Lipid-A-disaccharide synthase"
FT                   /id="PRO_0000190159"
FT   REGION          1..224
FT                   /note="Unknown"
FT   REGION          225..607
FT                   /note="Lipid-A-disaccharide synthase"
SQ   SEQUENCE   607 AA;  69198 MW;  F794FD9B10FBB259 CRC64;
     MFPQKITLWL YPLGLFANLF FGTAFCVQWF LIKKRGCSFV PKIFWHLSCS GAVLMICHGF
     IQSQYPIALL HSFNLIIYFR NLNIASSTPL PISKIVSLLV VSATAITLSF AIGTQYLPHM
     TWMASPNILH LNLPEANFLW QLIGCIGLTI FSLRFFIQWF YLEYKNQSSL PTPFWKASLV
     GGSICLIYFL RTGDIVNVLC YGCGLFPSLA NLRIASREAI QKPFSCSCFI SAGEHSGDTL
     GGNLLKEIHA KYPDIHCFGV GGPQMRAQNF CTLFSMEKFQ ISGFWEVLLA LPKLWYRRRI
     LYKTILKRNP QAVICIDFPD FHFLLIKKLR SLGYKGKIVH YVCPSIWAWR PSRKTTLEKY
     LDLLLLILPF EQKLFKDSPL RTVYIGHPLS ETIKLFCPKQ NWKERLHLPT DKPFVAAFPG
     SRHSDILRNL TIQVQAFQAS DFASTHHLLV SSANPAYDHL ILEILQQNRC LHSNIVPSQF
     RYELMRECDC ALAKCGTIVL ETALNLTPTI VTCQLRPLDT FLAKYIFNII LPAYSLPNII
     LGRTIFPEFI GGKKDFRYED VAAALNILKT SQAQEKQKNA CKDVYQAINE SASTIKECLP
     FIFEASY