ID   LPXB_RICPR              Reviewed;         380 AA.
AC   Q9ZDK7;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Lipid-A-disaccharide synthase;
DE            EC=2.4.1.182;
GN   Name=lpxB; OrderedLocusNames=RP321;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA   Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA   Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: Condensation of UDP-2,3-diacylglucosamine and 2,3-
CC       diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor
CC       of lipid A, a phosphorylated glycolipid that anchors the
CC       lipopolysaccharide to the outer membrane of the cell. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-
CC         glucosamine = a lipid A disaccharide + H(+) + UDP;
CC         Xref=Rhea:RHEA:67828, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:137748, ChEBI:CHEBI:176338, ChEBI:CHEBI:176343;
CC         EC=2.4.1.182;
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.
CC   -!- SIMILARITY: Belongs to the LpxB family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ235271; CAA14781.1; -; Genomic_DNA.
DR   PIR; C71688; C71688.
DR   RefSeq; NP_220704.1; NC_000963.1.
DR   RefSeq; WP_004597431.1; NC_000963.1.
DR   AlphaFoldDB; Q9ZDK7; -.
DR   SMR; Q9ZDK7; -.
DR   STRING; 272947.RP321; -.
DR   CAZy; GT19; Glycosyltransferase Family 19.
DR   EnsemblBacteria; CAA14781; CAA14781; CAA14781.
DR   GeneID; 57569447; -.
DR   KEGG; rpr:RP321; -.
DR   PATRIC; fig|272947.5.peg.330; -.
DR   eggNOG; COG0763; Bacteria.
DR   HOGENOM; CLU_036577_2_0_5; -.
DR   OMA; PTVWAWR; -.
DR   UniPathway; UPA00973; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0008915; F:lipid-A-disaccharide synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00392; LpxB; 1.
DR   InterPro; IPR003835; Glyco_trans_19.
DR   PANTHER; PTHR30372; PTHR30372; 1.
DR   Pfam; PF02684; LpxB; 1.
DR   TIGRFAMs; TIGR00215; lpxB; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Lipid A biosynthesis; Lipid biosynthesis;
KW   Lipid metabolism; Reference proteome; Transferase.
FT   CHAIN           1..380
FT                   /note="Lipid-A-disaccharide synthase"
FT                   /id="PRO_0000190182"
SQ   SEQUENCE   380 AA;  43249 MW;  E8718E4C5E6ECDD1 CRC64;
     MKKIYFIAGE MSGDFIGGHV IQNLKSNEGL EFTGIGGKYM EEAGNFKSLF TITAINLIGF
     IEIIPHLLKI KKLIDKTVEH IINSKADLLI TIDSPGFTYR VAKRVRKLLP NLKMIHIVAP
     SVWAYKADRA VNYAKIYDCL FALLPFEPPY FTKVGLDCRY IGHPIMEQEF YRDKIALRKE
     LKIDENERIL CVTLGTRKGE ILRHLPIFID AIQEISKDYK NLTIIFPLAH PDHEAIIKPF
     LDNIQFNYLF LSNERLKAYA VSDLALAKSG TNTLEISASG TPMVVAYKVN IISFIIIMLL
     IKIKYVSLIN IIAGSEIIPE FIQFNCKANL ISNKLKELLS NSQKRYNQVV KSKKILQKLG
     FESNRSPSYI AAKIIKQEFL