5HT5A_HUMAN
ID 5HT5A_HUMAN Reviewed; 357 AA.
AC P47898; Q2M2D2;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=5-hydroxytryptamine receptor 5A;
DE Short=5-HT-5;
DE Short=5-HT-5A;
DE Short=5-HT5A;
DE AltName: Full=Serotonin receptor 5A;
GN Name=HTR5A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7988681; DOI=10.1016/0014-5793(94)01209-1;
RA Rees S., den Daas I., Foord S., Goodson S., Bull D., Kilpatrick G., Lee M.;
RT "Cloning and characterisation of the human 5-HT5A serotonin receptor.";
RL FEBS Lett. 355:242-246(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP VARIANT [LARGE SCALE ANALYSIS] CYS-262.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: This is one of the several different receptors for 5-
CC hydroxytryptamine (serotonin), a biogenic hormone that functions as a
CC neurotransmitter, a hormone, and a mitogen. The activity of this
CC receptor is mediated by G proteins.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; X81411; CAA57168.1; -; Genomic_DNA.
DR EMBL; X81412; CAA57168.1; JOINED; Genomic_DNA.
DR EMBL; AF498985; AAM21132.1; -; mRNA.
DR EMBL; BC112021; AAI12022.1; -; mRNA.
DR CCDS; CCDS5936.1; -.
DR PIR; I37107; I37107.
DR RefSeq; NP_076917.1; NM_024012.3.
DR AlphaFoldDB; P47898; -.
DR SMR; P47898; -.
DR BioGRID; 109593; 1.
DR IntAct; P47898; 1.
DR MINT; P47898; -.
DR STRING; 9606.ENSP00000287907; -.
DR BindingDB; P47898; -.
DR ChEMBL; CHEMBL3426; -.
DR DrugBank; DB01238; Aripiprazole.
DR DrugBank; DB06216; Asenapine.
DR DrugBank; DB00408; Loxapine.
DR DrugBank; DB00246; Ziprasidone.
DR DrugCentral; P47898; -.
DR GuidetoPHARMACOLOGY; 10; -.
DR GlyGen; P47898; 2 sites.
DR iPTMnet; P47898; -.
DR PhosphoSitePlus; P47898; -.
DR BioMuta; HTR5A; -.
DR DMDM; 1345607; -.
DR PaxDb; P47898; -.
DR PeptideAtlas; P47898; -.
DR PRIDE; P47898; -.
DR Antibodypedia; 18848; 357 antibodies from 30 providers.
DR DNASU; 3361; -.
DR Ensembl; ENST00000287907.3; ENSP00000287907.2; ENSG00000157219.5.
DR GeneID; 3361; -.
DR KEGG; hsa:3361; -.
DR MANE-Select; ENST00000287907.3; ENSP00000287907.2; NM_024012.4; NP_076917.1.
DR UCSC; uc003wlu.3; human.
DR CTD; 3361; -.
DR DisGeNET; 3361; -.
DR GeneCards; HTR5A; -.
DR HGNC; HGNC:5300; HTR5A.
DR HPA; ENSG00000157219; Tissue enriched (brain).
DR MIM; 601305; gene.
DR neXtProt; NX_P47898; -.
DR OpenTargets; ENSG00000157219; -.
DR PharmGKB; PA29558; -.
DR VEuPathDB; HostDB:ENSG00000157219; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01010000222287; -.
DR HOGENOM; CLU_009579_11_6_1; -.
DR InParanoid; P47898; -.
DR OMA; RRISNIM; -.
DR OrthoDB; 817833at2759; -.
DR PhylomeDB; P47898; -.
DR TreeFam; TF316350; -.
DR PathwayCommons; P47898; -.
DR Reactome; R-HSA-390666; Serotonin receptors.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; P47898; -.
DR SIGNOR; P47898; -.
DR BioGRID-ORCS; 3361; 7 hits in 1064 CRISPR screens.
DR GeneWiki; 5-HT5A_receptor; -.
DR GenomeRNAi; 3361; -.
DR Pharos; P47898; Tchem.
DR PRO; PR:P47898; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P47898; protein.
DR Bgee; ENSG00000157219; Expressed in cerebellar hemisphere and 47 other tissues.
DR ExpressionAtlas; P47898; baseline and differential.
DR Genevisible; P47898; HS.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0099060; C:integral component of postsynaptic specialization membrane; IEA:Ensembl.
DR GO; GO:0043204; C:perikaryon; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IDA:MGI.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0051378; F:serotonin binding; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007198; P:adenylate cyclase-inhibiting serotonin receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
DR GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR InterPro; IPR001397; 5HT5A_rcpt.
DR InterPro; IPR002231; 5HT_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24247:SF108; PTHR24247:SF108; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00518; 5HT5ARECEPTR.
DR PRINTS; PR01101; 5HTRECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..357
FT /note="5-hydroxytryptamine receptor 5A"
FT /id="PRO_0000068969"
FT TOPO_DOM 1..40
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 41..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 64..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 79..99
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 100..115
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 116..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 138..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 159..181
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 182..198
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 220..282
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 283..303
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 304..320
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 321..341
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 342..357
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 120..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 262
FT /note="R -> C (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs746290830)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035753"
SQ SEQUENCE 357 AA; 40255 MW; 92F8A78C69169790 CRC64;
MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL VAATFAWNLL
VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH ELSGRRWQLG RRLCQLWIAC
DVLCCTASIW NVTAIALDRY WSITRHMEYT LRTRKCVSNV MIALTWALSA VISLAPLLFG
WGETYSEGSE ECQVSREPSY AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS
PISEAVEVKD SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP
FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK NFFSRQH
