5HT5A_RAT
ID 5HT5A_RAT Reviewed; 357 AA.
AC P35364;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=5-hydroxytryptamine receptor 5A;
DE Short=5-HT-5A;
DE Short=5-HT5A;
DE AltName: Full=REC17;
DE AltName: Full=Serotonin receptor 5A;
GN Name=Htr5a; Synonyms=5ht5a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=7682702; DOI=10.1073/pnas.90.8.3452;
RA Erlander M.G., Lovenberg T.W., Baron B.M., de Lecea L., Danielson P.E.,
RA Racke M., Slone A.L., Siegel B.W., Foye P.E., Cannon K., Burns J.E.,
RA Sutcliffe G.J.;
RT "Two members of a distinct subfamily of 5-hydroxytryptamine receptors
RT differentially expressed in rat brain.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:3452-3456(1993).
CC -!- FUNCTION: This is one of the several different receptors for 5-
CC hydroxytryptamine (serotonin), a biogenic hormone that functions as a
CC neurotransmitter, a hormone, and a mitogen. The activity of this
CC receptor is mediated by G proteins.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Central nervous system.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; L10072; AAA40615.1; -; mRNA.
DR PIR; B47472; B47472.
DR RefSeq; NP_037280.1; NM_013148.1.
DR AlphaFoldDB; P35364; -.
DR SMR; P35364; -.
DR STRING; 10116.ENSRNOP00000009317; -.
DR BindingDB; P35364; -.
DR ChEMBL; CHEMBL4655; -.
DR DrugCentral; P35364; -.
DR GuidetoPHARMACOLOGY; 10; -.
DR GlyGen; P35364; 2 sites.
DR PhosphoSitePlus; P35364; -.
DR PaxDb; P35364; -.
DR Ensembl; ENSRNOT00000009317; ENSRNOP00000009317; ENSRNOG00000007066.
DR GeneID; 25689; -.
DR KEGG; rno:25689; -.
DR CTD; 3361; -.
DR RGD; 2851; Htr5a.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01010000222287; -.
DR HOGENOM; CLU_009579_11_6_1; -.
DR InParanoid; P35364; -.
DR OMA; RRISNIM; -.
DR OrthoDB; 817833at2759; -.
DR PhylomeDB; P35364; -.
DR TreeFam; TF316350; -.
DR Reactome; R-RNO-390666; Serotonin receptors.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:P35364; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000007066; Expressed in frontal cortex and 1 other tissue.
DR Genevisible; P35364; RN.
DR GO; GO:0030425; C:dendrite; IDA:RGD.
DR GO; GO:0005794; C:Golgi apparatus; IDA:RGD.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0099060; C:integral component of postsynaptic specialization membrane; IDA:SynGO.
DR GO; GO:0043204; C:perikaryon; IDA:RGD.
DR GO; GO:0005791; C:rough endoplasmic reticulum; IDA:RGD.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IMP:RGD.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0051378; F:serotonin binding; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0007198; P:adenylate cyclase-inhibiting serotonin receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IEP:RGD.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IMP:RGD.
DR GO; GO:0021766; P:hippocampus development; IEP:RGD.
DR GO; GO:0032355; P:response to estradiol; IEP:RGD.
DR InterPro; IPR001397; 5HT5A_rcpt.
DR InterPro; IPR002231; 5HT_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24247:SF108; PTHR24247:SF108; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00518; 5HT5ARECEPTR.
DR PRINTS; PR01101; 5HTRECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..357
FT /note="5-hydroxytryptamine receptor 5A"
FT /id="PRO_0000068971"
FT TOPO_DOM 1..40
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 41..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 64..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 79..99
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 100..115
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 116..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 138..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 159..181
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 182..198
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 220..282
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 283..303
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 304..320
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 321..341
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 342..357
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 120..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 357 AA; 40673 MW; 8C498A50C88408B5 CRC64;
MDLPINLTSF SLSTPSTLEP NRSLDTEALR TSQSFLSAFR VLVLTLLGFL AAATFTWNLL
VLATILRVRT FHRVPHNLVA SMAISDVLVA VLVMPLSLVH ELSGRRWQLG RRLCQLWIAC
DVLCCTASIW NVTAIALDRY WSITRHLEYT LRARKRVSNV MILLTWALSA VISLAPLLFG
WGETYSELSE ECQVSREPSY TVFSTVGAFY LPLCVVLFVY WKIYKAAKFR MGSRKTNSVS
PIPEAVEVKD ASQHPQMVFT VRHATVTFQT EGDTWREQKE QRAALMVGIL IGVFVLCWFP
FFVTELISPL CSWDIPALWK SIFLWLGYSN SFFNPLIYTA FNRSYSSAFK VFFSKQQ
