5HT5B_RAT
ID 5HT5B_RAT Reviewed; 370 AA.
AC P35365;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=5-hydroxytryptamine receptor 5B;
DE Short=5-HT-5B;
DE Short=5-HT5B;
DE AltName: Full=MR22;
DE AltName: Full=Serotonin receptor 5B;
GN Name=Htr5b; Synonyms=5ht5b;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=7682702; DOI=10.1073/pnas.90.8.3452;
RA Erlander M.G., Lovenberg T.W., Baron B.M., de Lecea L., Danielson P.E.,
RA Racke M., Slone A.L., Siegel B.W., Foye P.E., Cannon K., Burns J.E.,
RA Sutcliffe G.J.;
RT "Two members of a distinct subfamily of 5-hydroxytryptamine receptors
RT differentially expressed in rat brain.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:3452-3456(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8224165; DOI=10.1016/0014-5793(93)80368-5;
RA Wisden W., Parker E.M., Mahle C.D., Grisel D.A., Nowak H.P., Yocca F.D.,
RA Felder C.C., Seeburg P.H., Voigt M.M.;
RT "Cloning and characterization of the rat 5-HT5B receptor. Evidence that the
RT 5-HT5B receptor couples to a G protein in mammalian cell membranes.";
RL FEBS Lett. 333:25-31(1993).
CC -!- FUNCTION: This is one of the several different receptors for 5-
CC hydroxytryptamine (serotonin), a biogenic hormone that functions as a
CC neurotransmitter, a hormone, and a mitogen. The activity of this
CC receptor is mediated by G proteins. Probably involved in anxiety and
CC depression.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Brain; in the CA1 region of hippocampus, the medial
CC habenula, and raphe nuclei.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; L10073; AAA40616.1; -; mRNA.
DR PIR; S38744; S38744.
DR RefSeq; NP_077371.1; NM_024395.1.
DR AlphaFoldDB; P35365; -.
DR SMR; P35365; -.
DR STRING; 10116.ENSRNOP00000003441; -.
DR BindingDB; P35365; -.
DR ChEMBL; CHEMBL2619; -.
DR DrugCentral; P35365; -.
DR GlyGen; P35365; 1 site.
DR PhosphoSitePlus; P35365; -.
DR PaxDb; P35365; -.
DR Ensembl; ENSRNOT00000003441; ENSRNOP00000003441; ENSRNOG00000002549.
DR GeneID; 79247; -.
DR KEGG; rno:79247; -.
DR UCSC; RGD:62388; rat.
DR CTD; 15564; -.
DR RGD; 62388; Htr5b.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01010000222287; -.
DR HOGENOM; CLU_009579_11_6_1; -.
DR InParanoid; P35365; -.
DR OMA; LFGWGEV; -.
DR OrthoDB; 817833at2759; -.
DR PhylomeDB; P35365; -.
DR TreeFam; TF316350; -.
DR PRO; PR:P35365; -.
DR Proteomes; UP000002494; Chromosome 13.
DR Bgee; ENSRNOG00000002549; Expressed in Ammon's horn and 3 other tissues.
DR Genevisible; P35365; RN.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IDA:RGD.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; ISO:RGD.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0051378; F:serotonin binding; IBA:GO_Central.
DR GO; GO:0007198; P:adenylate cyclase-inhibiting serotonin receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR InterPro; IPR000431; 5HT5B_rcpt.
DR InterPro; IPR002231; 5HT_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00519; 5HT5BRECEPTR.
DR PRINTS; PR01101; 5HTRECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..370
FT /note="5-hydroxytryptamine receptor 5B"
FT /id="PRO_0000068973"
FT TOPO_DOM 1..52
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 53..75
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 76..90
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 91..111
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 112..128
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 129..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 151..171
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 172..194
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 195..211
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 212..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 233..295
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 296..316
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 317..333
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 334..354
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 355..370
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 127..205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 370 AA; 41122 MW; 8EC5F789BFD647E5 CRC64;
MEVSNLSGAT PGIAFPPGPE SCSDSPSSGR SMGSTPGGLI LSGREPPFSA FTVLVVTLLV
LLIAATFLWN LLVLVTILRV RAFHRVPHNL VASTAVSDVL VAALVMPLSL VSELSAGRRW
QLGRSLCHVW ISFDVLCCTA SIWNVAAIAL DRYWTITRHL QYTLRTRRRA SALMIAITWA
LSALIALAPL LFGWGEAYDA RLQRCQVSQE PSYAVFSTCG AFYVPLAVVL FVYWKIYKAA
KFRFGRRRRA VVPLPATTQA KEAPQESETV FTARCRATVA FQTSGDSWRE QKEKRAAMMV
GILIGVFVLC WIPFFLTELV SPLCACSLPP IWKSIFLWLG YSNSFFNPLI YTAFNKNYNN
AFKSLFTKQR
