ID   LR10B_HUMAN             Reviewed;         292 AA.
AC   A6NIK2;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Leucine-rich repeat-containing protein 10B;
GN   Name=LRRC10B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
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DR   EMBL; AP003108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS44621.1; -.
DR   RefSeq; NP_001138549.1; NM_001145077.1.
DR   AlphaFoldDB; A6NIK2; -.
DR   SMR; A6NIK2; -.
DR   BioGRID; 133444; 4.
DR   STRING; 9606.ENSP00000367315; -.
DR   iPTMnet; A6NIK2; -.
DR   PhosphoSitePlus; A6NIK2; -.
DR   BioMuta; LRRC10B; -.
DR   jPOST; A6NIK2; -.
DR   MassIVE; A6NIK2; -.
DR   PaxDb; A6NIK2; -.
DR   PeptideAtlas; A6NIK2; -.
DR   PRIDE; A6NIK2; -.
DR   Antibodypedia; 67383; 15 antibodies from 8 providers.
DR   DNASU; 390205; -.
DR   Ensembl; ENST00000378075.4; ENSP00000367315.2; ENSG00000204950.4.
DR   GeneID; 390205; -.
DR   KEGG; hsa:390205; -.
DR   MANE-Select; ENST00000378075.4; ENSP00000367315.2; NM_001145077.2; NP_001138549.1.
DR   UCSC; uc010rlk.2; human.
DR   CTD; 390205; -.
DR   DisGeNET; 390205; -.
DR   GeneCards; LRRC10B; -.
DR   HGNC; HGNC:37215; LRRC10B.
DR   HPA; ENSG00000204950; Group enriched (brain, fallopian tube, pituitary gland).
DR   neXtProt; NX_A6NIK2; -.
DR   OpenTargets; ENSG00000204950; -.
DR   PharmGKB; PA165543456; -.
DR   VEuPathDB; HostDB:ENSG00000204950; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000155040; -.
DR   HOGENOM; CLU_000288_18_15_1; -.
DR   InParanoid; A6NIK2; -.
DR   OMA; NELMEVP; -.
DR   OrthoDB; 1136570at2759; -.
DR   PhylomeDB; A6NIK2; -.
DR   TreeFam; TF332853; -.
DR   PathwayCommons; A6NIK2; -.
DR   SignaLink; A6NIK2; -.
DR   BioGRID-ORCS; 390205; 17 hits in 1061 CRISPR screens.
DR   GenomeRNAi; 390205; -.
DR   Pharos; A6NIK2; Tdark.
DR   PRO; PR:A6NIK2; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; A6NIK2; protein.
DR   Bgee; ENSG00000204950; Expressed in bronchial epithelial cell and 135 other tissues.
DR   Genevisible; A6NIK2; HS.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 5.
DR   PROSITE; PS51450; LRR; 7.
PE   4: Predicted;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..292
FT                   /note="Leucine-rich repeat-containing protein 10B"
FT                   /id="PRO_0000346162"
FT   REPEAT          22..43
FT                   /note="LRR 1"
FT   REPEAT          45..66
FT                   /note="LRR 2"
FT   REPEAT          68..90
FT                   /note="LRR 3"
FT   REPEAT          91..112
FT                   /note="LRR 4"
FT   REPEAT          114..136
FT                   /note="LRR 5"
FT   REPEAT          137..158
FT                   /note="LRR 6"
FT   REPEAT          160..181
FT                   /note="LRR 7"
FT   REPEAT          183..204
FT                   /note="LRR 8"
FT   REPEAT          205..226
FT                   /note="LRR 9"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..258
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   292 AA;  32714 MW;  C17ECE528B57EE39 CRC64;
     MGIAESTPDE LPSDAEEQLR SGDQQLELSG RRLRRLPSAV CALSRLQKLY VSGTGLRELP
     EEIEELRELR ILALDFNKLE RLPDGLCRLP RLTRLYLGGN RLLALPADFA QLQSLRCLWI
     EGNFLRRFPR PLLRLVALQS LQMGDNRLRA LPAELPRMTG LRGLWLYGNR FEEFPPALLR
     MGRLHILDLD RNRLGGFPDL HPLRALRVFS YDHNPVTGPP RVADTVFLVG EGAVERMAER
     DEPTPRPPPR RPARAFEDEE EEDLLIGGAG SRALGAPGGS FRALEAAPGL GT