LR14B_DANRE
ID LR14B_DANRE Reviewed; 526 AA.
AC Q1L8H0;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Leucine-rich repeat-containing protein 14B {ECO:0000250|UniProtKB:A6NHZ5};
GN Name=lrrc14b {ECO:0000250|UniProtKB:A6NHZ5}; ORFNames=si:dkey-231l1.3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SIMILARITY: Belongs to the PRAME family. LRRC14 subfamily.
CC {ECO:0000305}.
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DR EMBL; CR786578; CAK10737.1; -; Genomic_DNA.
DR RefSeq; NP_001038578.1; NM_001045113.1.
DR AlphaFoldDB; Q1L8H0; -.
DR SMR; Q1L8H0; -.
DR STRING; 7955.ENSDARP00000080475; -.
DR PaxDb; Q1L8H0; -.
DR Ensembl; ENSDART00000086040; ENSDARP00000080475; ENSDARG00000060788.
DR GeneID; 566643; -.
DR KEGG; dre:566643; -.
DR CTD; 389257; -.
DR ZFIN; ZDB-GENE-060503-910; lrrc14b.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_0_0_1; -.
DR InParanoid; Q1L8H0; -.
DR OMA; TCCELQA; -.
DR OrthoDB; 563553at2759; -.
DR PhylomeDB; Q1L8H0; -.
DR TreeFam; TF332708; -.
DR PRO; PR:Q1L8H0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000060788; Expressed in muscle tissue and 7 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..526
FT /note="Leucine-rich repeat-containing protein 14B"
FT /id="PRO_0000344242"
FT REPEAT 103..140
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 191..215
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 244..279
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 280..304
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 305..336
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 337..355
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 361..388
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 389..413
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ SEQUENCE 526 AA; 59532 MW; 651E5C1693AC56BD CRC64;
MKTLKFLSAE AFVQTGPNAR RNLHCLSYNL YPILFKASYL HEEASFLHDL VQTWPLTELN
LRKLLGKTTD CPEDLTCSTC RLCLEAFLTG LRDYVLQAST TYAKILQVVD LIGIRDTEHQ
ICQCRRTLGR WARTEMLTRV CYETMVSMQA GQSAPSAFNV EVDVRLDAFV TGRNYEVVSQ
ALLLRRHCPL KLQFVGLRVD SLSLRNLFYL LKLVESHGPQ KLEVVHNVHL EAPHIEVMLS
QLKFPRLRSL TFPAQALNVH RLGLEDQDLM RVLGELMSKL TELRELYLGF STLTGHLRKL
LSPLNTPLEC IELANCSINA LDMAYFANSL HSEHLVKLDL SGHEVADLFP NTFRKLLQRC
SSTLISLGLE ECGLDDEKLD LLTQALTPCH GLQELKILGN PLTSAALHRL FNTLANAYPA
LRYVELPVPR DCYPESVTYP LDDRTLVNYD SDKFQQARTE LVGILEREGK GHVEVCTPLL
GVYDADINET SNELGVSMLS SFNNVIGSFI DTVNTVTQRR EHRLME
