LR14B_HUMAN
ID LR14B_HUMAN Reviewed; 514 AA.
AC A6NHZ5;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 3.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Leucine-rich repeat-containing protein 14B {ECO:0000305};
GN Name=LRRC14B {ECO:0000312|HGNC:HGNC:37268};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
CC -!- SIMILARITY: Belongs to the PRAME family. LRRC14 subfamily.
CC {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AC021087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS47184.1; -.
DR RefSeq; NP_001073947.1; NM_001080478.2.
DR AlphaFoldDB; A6NHZ5; -.
DR SMR; A6NHZ5; -.
DR BioGRID; 133062; 22.
DR IntAct; A6NHZ5; 2.
DR MINT; A6NHZ5; -.
DR STRING; 9606.ENSP00000327675; -.
DR GlyGen; A6NHZ5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; A6NHZ5; -.
DR PhosphoSitePlus; A6NHZ5; -.
DR SwissPalm; A6NHZ5; -.
DR BioMuta; LRRC14B; -.
DR MassIVE; A6NHZ5; -.
DR PaxDb; A6NHZ5; -.
DR PeptideAtlas; A6NHZ5; -.
DR PRIDE; A6NHZ5; -.
DR ProteomicsDB; 1234; -.
DR Antibodypedia; 49983; 75 antibodies from 15 providers.
DR DNASU; 389257; -.
DR Ensembl; ENST00000328278.4; ENSP00000327675.3; ENSG00000185028.4.
DR GeneID; 389257; -.
DR KEGG; hsa:389257; -.
DR MANE-Select; ENST00000328278.4; ENSP00000327675.3; NM_001080478.3; NP_001073947.1.
DR UCSC; uc003jal.1; human.
DR CTD; 389257; -.
DR GeneCards; LRRC14B; -.
DR HGNC; HGNC:37268; LRRC14B.
DR HPA; ENSG00000185028; Tissue enriched (skeletal).
DR neXtProt; NX_A6NHZ5; -.
DR OpenTargets; ENSG00000185028; -.
DR VEuPathDB; HostDB:ENSG00000185028; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_0_0_1; -.
DR InParanoid; A6NHZ5; -.
DR OMA; TCCELQA; -.
DR OrthoDB; 563553at2759; -.
DR PhylomeDB; A6NHZ5; -.
DR TreeFam; TF332708; -.
DR PathwayCommons; A6NHZ5; -.
DR SignaLink; A6NHZ5; -.
DR BioGRID-ORCS; 389257; 15 hits in 1067 CRISPR screens.
DR GenomeRNAi; 389257; -.
DR Pharos; A6NHZ5; Tdark.
DR PRO; PR:A6NHZ5; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; A6NHZ5; protein.
DR Bgee; ENSG00000185028; Expressed in apex of heart and 48 other tissues.
DR Genevisible; A6NHZ5; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
PE 3: Inferred from homology;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..514
FT /note="Leucine-rich repeat-containing protein 14B"
FT /id="PRO_0000344240"
FT REPEAT 104..141
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 185..209
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 238..277
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 278..302
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 303..334
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 335..350
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 359..386
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 387..411
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ SEQUENCE 514 AA; 56758 MW; 61F7F004766CF7C9 CRC64;
MDTMRSLRFI SAEALVSHPQ VARQSLDSVA HNLYPLLFKA SYLLEQAEVT RAVLGRWPLE
EFRLGALLGP GADHPQDLRD RTCRACLEAL VRGLADHVLQ DRSRRRLRVA DLTGIRDVQV
QRCPCGRALG RWGRTQLLAR TCCELQAEPL AAGRPVEVLA DLFVTEGNFE AVVQALRPAG
PAPLRVHCPS FRADSLSPSQ LLHVLRLAGP GALRKLEVVH NVRLHAGHVQ QLLAQVGFPR
LASLTLPTKA FDAPPTYAST PDGEDPLLAS IARELSKMAQ LTELSVAFST LTGKIPTLLG
PLQTPLRVLD LANCALNHTD MAFLADCAHA AHLEVLDLSG HNLVSLYPST FFRLLSQASR
TLRILTLEEC GIVDSHVGML ILGLSPCHRL RQLKFLGNPL SARALRRLFT ALCELPELRC
IEFPVPKDCY PEGAAYPQDE LAMSKFNQQK YDEIAEELRA VLLRADREDI QVSTPLFGSF
DPDIQETSNE LGAFLLQAFK TALENFSRAL KQIE
