LR14B_MOUSE
ID LR14B_MOUSE Reviewed; 510 AA.
AC Q3UJB3; Q6P1Y3;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Leucine-rich repeat-containing protein 14B {ECO:0000250|UniProtKB:A6NHZ5};
GN Name=Lrrc14b {ECO:0000312|MGI:MGI:2145269};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Amnion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Jaw, and Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the PRAME family. LRRC14 subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH64819.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK146537; BAE27242.1; -; mRNA.
DR EMBL; CH466563; EDL37094.1; -; Genomic_DNA.
DR EMBL; BC064819; AAH64819.1; ALT_INIT; mRNA.
DR EMBL; BC139119; AAI39120.1; -; mRNA.
DR EMBL; BC139120; AAI39121.1; -; mRNA.
DR CCDS; CCDS26645.1; -.
DR RefSeq; NP_001028214.1; NM_001033042.3.
DR AlphaFoldDB; Q3UJB3; -.
DR STRING; 10090.ENSMUSP00000022064; -.
DR iPTMnet; Q3UJB3; -.
DR PhosphoSitePlus; Q3UJB3; -.
DR PaxDb; Q3UJB3; -.
DR PRIDE; Q3UJB3; -.
DR ProteomicsDB; 252491; -.
DR Antibodypedia; 49983; 75 antibodies from 15 providers.
DR Ensembl; ENSMUST00000022064; ENSMUSP00000022064; ENSMUSG00000021579.
DR GeneID; 432779; -.
DR KEGG; mmu:432779; -.
DR UCSC; uc007rfe.1; mouse.
DR CTD; 389257; -.
DR MGI; MGI:2145269; Lrrc14b.
DR VEuPathDB; HostDB:ENSMUSG00000021579; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_0_0_1; -.
DR InParanoid; Q3UJB3; -.
DR OMA; TCCELQA; -.
DR OrthoDB; 563553at2759; -.
DR PhylomeDB; Q3UJB3; -.
DR TreeFam; TF332708; -.
DR BioGRID-ORCS; 432779; 2 hits in 38 CRISPR screens.
DR PRO; PR:Q3UJB3; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q3UJB3; protein.
DR Bgee; ENSMUSG00000021579; Expressed in hindlimb stylopod muscle and 13 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..510
FT /note="Leucine-rich repeat-containing protein 14B"
FT /id="PRO_0000344241"
FT REPEAT 100..137
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 181..205
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 234..273
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 274..298
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 299..330
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 331..349
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 355..382
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 383..407
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ SEQUENCE 510 AA; 56543 MW; 4367FCF669417060 CRC64;
MRSLRFISAE ALVSHSQLVQ ENLDNIAYNL YPLLFKASYL LEQADVTRAL LSHWPLEEFR
LAVLLRPNTD HPEDLRDRAC KACLEACMQG IADHVLKSGS NRLRVADFTG IQDVQVQQCP
CGRALGRWGR TKVLARTCCQ LQGQPCSAGH PIEVFADLFV TEGNFDMVVQ ALKPLGPAPL
QVCCPSLRAD SLSPGQLLQV LGLAGPGNLR KLEVVHNVRL HAGHVQQLLT QVGFPQLTSL
TLPTKAFDAP PTCAPDPEGE DLLLTSIAWE LSQMNQLTEL SVAFSTLTGK IQTLLSPLKT
PLRVLDLANC ALNHEDISFL ADCNHTAHLE VLDLSGHNLV HLYPSTFFRL LSQAAQTLRV
LTLEECNITD SHVNMMILGL SPCSQLQQFK FLGNPLSGSA LRRLFAALCE LPRLRHIEFP
VPKDCYPEGA IYPQDELSVS KFDQQKYDVI AEDLRAVLLR ANREDIQVST PLFGSFDPDI
HETSNELGTF LLQAFKTALE NFSRALEQME
