LR2BP_HUMAN
ID LR2BP_HUMAN Reviewed; 347 AA.
AC Q9P2M1; A6NJR7; A7E219; B3KX83; Q9NSN6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=LRP2-binding protein;
DE AltName: Full=Megalin-binding protein;
DE Short=MegBP;
GN Name=LRP2BP; Synonyms=KIAA1325;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH LRP2.
RX PubMed=12508107; DOI=10.1242/jcs.00243;
RA Petersen H.H., Hilpert J., Militz D., Zandler V., Jacobsen C.,
RA Roebroek A.J.M., Willnow T.E.;
RT "Functional interaction of megalin with the megalin-binding protein
RT (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.";
RL J. Cell Sci. 116:453-461(2003).
CC -!- FUNCTION: May act as an adapter that regulates LRP2 function.
CC -!- SUBUNIT: Interacts with LRP2. {ECO:0000269|PubMed:12508107}.
CC -!- INTERACTION:
CC Q9P2M1; Q9BV19: C1orf50; NbExp=3; IntAct=EBI-18273118, EBI-2874661;
CC Q9P2M1; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-18273118, EBI-1104933;
CC Q9P2M1; Q8IVW4: CDKL3; NbExp=3; IntAct=EBI-18273118, EBI-3919850;
CC Q9P2M1; P38936: CDKN1A; NbExp=3; IntAct=EBI-18273118, EBI-375077;
CC Q9P2M1; Q86UW9: DTX2; NbExp=3; IntAct=EBI-18273118, EBI-740376;
CC Q9P2M1; Q6NZ36-4: FAAP20; NbExp=3; IntAct=EBI-18273118, EBI-12013806;
CC Q9P2M1; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-18273118, EBI-6658203;
CC Q9P2M1; Q8NHY3: GAS2L2; NbExp=3; IntAct=EBI-18273118, EBI-7960826;
CC Q9P2M1; P55040: GEM; NbExp=3; IntAct=EBI-18273118, EBI-744104;
CC Q9P2M1; Q92917: GPKOW; NbExp=3; IntAct=EBI-18273118, EBI-746309;
CC Q9P2M1; P09211: GSTP1; NbExp=3; IntAct=EBI-18273118, EBI-353467;
CC Q9P2M1; P31273: HOXC8; NbExp=3; IntAct=EBI-18273118, EBI-1752118;
CC Q9P2M1; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-18273118, EBI-726510;
CC Q9P2M1; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-18273118, EBI-10181968;
CC Q9P2M1; Q14088: RAB33A; NbExp=3; IntAct=EBI-18273118, EBI-744685;
CC Q9P2M1; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-18273118, EBI-748391;
CC Q9P2M1; Q92922: SMARCC1; NbExp=3; IntAct=EBI-18273118, EBI-355653;
CC Q9P2M1; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-18273118, EBI-6427977;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12508107}.
CC Note=Detected in a vesicular staining pattern close to the plasma
CC membrane and throughout the cytoplasm.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9P2M1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9P2M1-2; Sequence=VSP_030664;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA92563.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB037746; BAA92563.1; ALT_INIT; mRNA.
DR EMBL; AK126913; BAG54395.1; -; mRNA.
DR EMBL; AL161975; CAB82313.2; -; mRNA.
DR EMBL; AC106897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471056; EAX04650.1; -; Genomic_DNA.
DR EMBL; BC150161; AAI50162.1; -; mRNA.
DR EMBL; BC152444; AAI52445.1; -; mRNA.
DR CCDS; CCDS3840.1; -. [Q9P2M1-1]
DR PIR; T47138; T47138.
DR RefSeq; NP_060879.2; NM_018409.3. [Q9P2M1-1]
DR RefSeq; XP_006714323.1; XM_006714260.3.
DR RefSeq; XP_016863899.1; XM_017008410.1. [Q9P2M1-1]
DR AlphaFoldDB; Q9P2M1; -.
DR SMR; Q9P2M1; -.
DR BioGRID; 120916; 23.
DR IntAct; Q9P2M1; 20.
DR STRING; 9606.ENSP00000332681; -.
DR iPTMnet; Q9P2M1; -.
DR PhosphoSitePlus; Q9P2M1; -.
DR BioMuta; LRP2BP; -.
DR DMDM; 166199159; -.
DR MassIVE; Q9P2M1; -.
DR PaxDb; Q9P2M1; -.
DR PeptideAtlas; Q9P2M1; -.
DR PRIDE; Q9P2M1; -.
DR ProteomicsDB; 83845; -. [Q9P2M1-1]
DR ProteomicsDB; 83846; -. [Q9P2M1-2]
DR Antibodypedia; 28937; 67 antibodies from 18 providers.
DR DNASU; 55805; -.
DR Ensembl; ENST00000328559.11; ENSP00000332681.7; ENSG00000109771.16. [Q9P2M1-1]
DR Ensembl; ENST00000505916.6; ENSP00000426203.1; ENSG00000109771.16. [Q9P2M1-1]
DR GeneID; 55805; -.
DR KEGG; hsa:55805; -.
DR MANE-Select; ENST00000505916.6; ENSP00000426203.1; NM_001377440.1; NP_001364369.1.
DR UCSC; uc003ixj.3; human. [Q9P2M1-1]
DR CTD; 55805; -.
DR DisGeNET; 55805; -.
DR GeneCards; LRP2BP; -.
DR HGNC; HGNC:25434; LRP2BP.
DR HPA; ENSG00000109771; Tissue enhanced (pituitary gland, retina).
DR MIM; 619020; gene.
DR neXtProt; NX_Q9P2M1; -.
DR OpenTargets; ENSG00000109771; -.
DR PharmGKB; PA142671538; -.
DR VEuPathDB; HostDB:ENSG00000109771; -.
DR eggNOG; KOG1550; Eukaryota.
DR GeneTree; ENSGT00390000013490; -.
DR InParanoid; Q9P2M1; -.
DR OMA; VMYLYGQ; -.
DR OrthoDB; 1039341at2759; -.
DR PhylomeDB; Q9P2M1; -.
DR TreeFam; TF315257; -.
DR PathwayCommons; Q9P2M1; -.
DR SignaLink; Q9P2M1; -.
DR BioGRID-ORCS; 55805; 5 hits in 1068 CRISPR screens.
DR GenomeRNAi; 55805; -.
DR Pharos; Q9P2M1; Tbio.
DR PRO; PR:Q9P2M1; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q9P2M1; protein.
DR Bgee; ENSG00000109771; Expressed in sperm and 105 other tissues.
DR ExpressionAtlas; Q9P2M1; baseline and differential.
DR Genevisible; Q9P2M1; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF08238; Sel1; 5.
DR SMART; SM00671; SEL1; 5.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..347
FT /note="LRP2-binding protein"
FT /id="PRO_0000315707"
FT REPEAT 59..92
FT /note="TPR"
FT REPEAT 93..125
FT /note="Sel1-like 1"
FT REPEAT 133..168
FT /note="Sel1-like 2"
FT REPEAT 173..206
FT /note="Sel1-like 3"
FT REPEAT 207..242
FT /note="Sel1-like 4"
FT REPEAT 243..277
FT /note="Sel1-like 5"
FT REPEAT 297..332
FT /note="Sel1-like 6"
FT VAR_SEQ 35
FT /note="T -> TKS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_030664"
SQ SEQUENCE 347 AA; 39780 MW; 6BC7C6E758A63F33 CRC64;
MKLTSEKLPK NPFYASVSQY AAKNQKFFQW KKEKTDYTHA NLVDKALQLL KERILKGDTL
AYFLRGQLYF EEGWYEEALE QFEEIKEKDH QATYQLGVMY YDGLGTTLDA EKGVDYMKKI
LDSPCPKARH LKFAAAYNLG RAYYEGKGVK RSNEEAERLW LIAADNGNPK ASVKAQSMLG
LYYSTKEPKE LEKAFYWHSE ACGNGNLESQ GALGLMYLYG QGIRQDTEAA LQCLREAAER
GNVYAQGNLV EYYYKMKFFT KCVAFSKRIA DYDEVHDIPM IAQVTDCLPE FIGRGMAMAS
FYHARCLQLG LGITRDETTA KHYYSKACRL NPALADELHS LLIRQRI
