LR2BP_MOUSE
ID LR2BP_MOUSE Reviewed; 346 AA.
AC Q9D4C6; Q3UV46; Q8CF18; Q8K0N7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=LRP2-binding protein;
GN Name=Lrp2bp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Bone, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as an adapter that regulates LRP2 function.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with LRP2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Detected in a
CC vesicular staining pattern close to the plasma membrane and throughout
CC the cytoplasm. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D4C6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D4C6-2; Sequence=VSP_030665;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC25168.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK016626; BAB30345.1; -; mRNA.
DR EMBL; AK007202; BAC25168.1; ALT_FRAME; mRNA.
DR EMBL; AK137605; BAE23427.1; -; mRNA.
DR EMBL; BC030908; AAH30908.1; -; mRNA.
DR EMBL; BC051150; AAH51150.1; -; mRNA.
DR CCDS; CCDS22286.1; -. [Q9D4C6-1]
DR RefSeq; NP_080554.1; NM_026278.3. [Q9D4C6-1]
DR AlphaFoldDB; Q9D4C6; -.
DR SMR; Q9D4C6; -.
DR STRING; 10090.ENSMUSP00000106010; -.
DR PhosphoSitePlus; Q9D4C6; -.
DR PaxDb; Q9D4C6; -.
DR PRIDE; Q9D4C6; -.
DR ProteomicsDB; 252492; -. [Q9D4C6-1]
DR ProteomicsDB; 252493; -. [Q9D4C6-2]
DR Antibodypedia; 28937; 67 antibodies from 18 providers.
DR Ensembl; ENSMUST00000110380; ENSMUSP00000106009; ENSMUSG00000031637. [Q9D4C6-1]
DR Ensembl; ENSMUST00000110381; ENSMUSP00000106010; ENSMUSG00000031637. [Q9D4C6-1]
DR GeneID; 67620; -.
DR KEGG; mmu:67620; -.
DR UCSC; uc009lpt.1; mouse. [Q9D4C6-1]
DR CTD; 55805; -.
DR MGI; MGI:1914870; Lrp2bp.
DR VEuPathDB; HostDB:ENSMUSG00000031637; -.
DR eggNOG; KOG1550; Eukaryota.
DR GeneTree; ENSGT00390000013490; -.
DR HOGENOM; CLU_068264_0_0_1; -.
DR InParanoid; Q9D4C6; -.
DR OrthoDB; 1039341at2759; -.
DR PhylomeDB; Q9D4C6; -.
DR TreeFam; TF315257; -.
DR BioGRID-ORCS; 67620; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Lrp2bp; mouse.
DR PRO; PR:Q9D4C6; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9D4C6; protein.
DR Bgee; ENSMUSG00000031637; Expressed in spermatid and 147 other tissues.
DR ExpressionAtlas; Q9D4C6; baseline and differential.
DR Genevisible; Q9D4C6; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF08238; Sel1; 5.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00671; SEL1; 5.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..346
FT /note="LRP2-binding protein"
FT /id="PRO_0000315709"
FT REPEAT 58..91
FT /note="TPR"
FT REPEAT 92..124
FT /note="Sel1-like 1"
FT REPEAT 132..167
FT /note="Sel1-like 2"
FT REPEAT 172..205
FT /note="Sel1-like 3"
FT REPEAT 206..241
FT /note="Sel1-like 4"
FT REPEAT 242..276
FT /note="Sel1-like 5"
FT REPEAT 296..331
FT /note="Sel1-like 6"
FT VAR_SEQ 1..214
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030665"
FT CONFLICT 149
FT /note="K -> E (in Ref. 1; BAC25168)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 346 AA; 39746 MW; C443C1475697E2D7 CRC64;
MKLSSEKLPK NPFSLSQYAA KQQKFFQWKK EKPDYYLHAN LVDTALQFLK ERIRRGDAMA
YFLRGQLYFE EGWYEEALAQ FEEIQEKDHQ AIYQLGVMYY DGLGTIANAE KGVNYMRKIL
DSSCPQTMHL KFAAAYNLGR AYFEGKGVKR SDEEAERLWL LAADNGNPKA SVKAQSILGL
FYSMKEPKEL EKAFFWHSEA CGNGSLESQG ALGLMYFYGQ GIRQDTDAAL HCLREAAERG
NVYAQGTLVE YYYKMKFFTK CVSFSKRIAD YDEVHDIPMI AHVTDCLPEF IIKGMAMAAF
YHGRCLQLGL GIMKDEESAK HYYSKACRLN PTLADELHSL LIHQRI
